a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization")

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PubMed:24760868

We analyzed actin and tau in the PSD-enriched fraction from primary cortical neurons treated with jasplakinolide (Fig. 5E). We observed that increased neuronal F-actin content promotes concurrent tau enrichment (*p0.0150, 2-tailed Student’s t test; control 17.49  0.7755 vs jasplakinolide 27.02  2719, N  4 independent cultures; Fig. 5F). GLUA1, the membrane trafficking of which is known to be actin dependent, was increased (*p 0.0279, 2-tailed Student’s t test; control 16.91  1015 vs jasplakinolide 31.00  4.778, N  4 independent cultures). The amount of Fyn in the PSD was decreased (*p  0.0265, 2-tailed Student’s t test; control 27.25 5.003 vs jasplakinolide 11.71  1.786, N  4 independent cultures).

Related Edges 4

• a(MESH:jasplakinolide) increases p(HGNC:GRIA1)
• a(MESH:jasplakinolide) decreases p(HGNC:FYN)
• bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin")
• complex(GO:"filamentous actin") increases p(HGNC:MAPT)

MeSH

Post-Synaptic Density

Text Location

Results

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