act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8))

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PubMed:18500754

The location of the hsc70-binding site in the tau MTBR suggests that hsc70 cannot bind microtubule-associated tau. The location of the hsc70-binding site also suggests that hsc70 might compete with tubulin or microtubules for binding to tau. Our data implicating I308/V309 in tau’s binding to hsp70 similarly suggest that tau cannot bind simultaneously to hsp70 and microtubules. However, unlike hsc70, which does not associate directly with tubulin or microtubules (Gache et al. 2005), hsp70 binds microtubules, presumably through its N-terminus (Sanchez et al. 1994). This would allow hsp70 to simultaneously bind to tau through its C-terminal substrate-binding domain and to microtubules through its N-terminus.

Related Edges 7

• complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family")
• p(HBP:"microtubule-binding region") association p(HGNC:HSPA8)
• p(HBP:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily")
• p(HGNC:HSPA8) association p(HBP:"microtubule-binding region")
• act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule))
• p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule)
• p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(HBP:"microtubule-binding region")

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