a(CHEBI:chloroquine) increases a(CHEBI:"N-retinylidene-N-retinylethanolamine")

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PubMed:25784053

Reduced levels of lipofuscin, LC3, and p62 have been observed in motor neurons of SOD1(G85R) mice (92). Treatment with the autophagy inhibitor chloroquine restored lipofuscin, LC3, and p62 levels in motor neurons, suggesting that mutant SOD1 causes hyperactive autophagy in mice (92).

Related Edges 7

• a(CHEBI:chloroquine) decreases bp(GO:autophagy)
• a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A)
• a(CHEBI:chloroquine) increases p(HGNC:SQSTM1)
• p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:"N-retinylidene-N-retinylethanolamine")
• p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A)
• p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1)
• p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy)

Cell Ontology (CL)

motor neuron

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