p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process")

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PubMed:30444369

It enhances the expression of anti- apoptotic proteins, such as Bcl-2 and Bcl-xL, and down-regulates the expression of Bim, a pro-apoptotic factor, preventing programmed cell death. 90, 100 Estradiol also activates antioxidant systems to protect neuronal cells from apoptosis by upregulating the expression of manganese superoxide dismutase and glutathione peroxidase. 101

Related Edges 7

• a(PUBCHEM:5757) increases p(HGNC:BCL2)
• a(PUBCHEM:5757) increases p(HGNC:BCL2L1)
• a(PUBCHEM:5757) decreases p(HGNC:BCL2L11)
• a(PUBCHEM:5757) increases p(HGNC:SOD2)
• a(PUBCHEM:5757) increases p(FPLX:GPX)
• p(HGNC:BCL2) decreases bp(GO:"apoptotic process")
• p(HGNC:BCL2L11) increases bp(GO:"apoptotic process")

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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