p(HGNC:S100B) increases p(HGNC:MAPT, pmod(Ph))

View Subject View Object

PubMed:18494933

In addition, as revealed by Western blot, small interfering RNA and immunofluorescence analysis, S100B-induced JNK activation increased expression of Dickopff-1 that, in turn, promoted glycogen synthase kinase 3-beta phosphorylation and beta-catenin degradation, causing canonical Wnt pathway disruption and tau protein hyperphosphorylation.

Related Edges 6

• act(p(FPLX:JNK)) increases p(HGNC:DKK1)
• deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1)
• p(HGNC:DKK1) increases act(p(HGNC:GSK3B), ma(kin))
• p(HGNC:DKK1) positiveCorrelation deg(p(HGNC:CTNNB1))
• act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph))
• p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---