p(FPLX:PKC) increases p(HGNC:MAPT, pmod(Ph, Ser, 214))

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PubMed:17493042

A further potent detaching site is phosphoS214, which can be phosphorylated by PKA and other kinases of the AGC group (PKA/PKG/PKC group of protein kinases), and is up-regulated during mitosis (16, 63). Tau contains one or two cysteines in the repeat domain (C291 in R2, present in 4R isoforms, and C322 in R3), which can be engaged in intra- or intermolecular cross-linking affecting conformation, dimerization and aggregation (108).

Related Edges 3

• bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(Ph, Ser, 214))
• p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 214))
• p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(Ph, Ser, 214))

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