p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine))

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PubMed:19293145

In SHSY5Y cells, RNA interference (RNAi) knockdown of alpha7 enhanced Abeta toxicity (Qi et al., 2007), and alpha7 antagonists, but not alpha4beta2 antagonists, block galantamine protection of cultured rat neurons (Kihara et al., 2004). Donepezil protects cultured rat cortical neurons against Abeta toxicity through both alpha7 and non-alpha7 nAChRs (Takada et al., 2003). It is therefore likely that alpha7 nAChRs are the primary mediators of nicotine neuroprotection, but in some cells, non-alpha7 subtypes are also likely to contribute.

Related Edges 6

• act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity)
• a(CHEBI:donepezil) decreases path(HBP:neurotoxicity)
• a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
• act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection)
• p(HGNC:CHRNA7) decreases act(a(CHEBI:"amyloid-beta"))
• p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine))

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