a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2)

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PubMed:19293145

Whatever the mechanism of uptake, it is interesting to note that the signaling pathways evoked by the accumulation of intracellular Abeta resemble those evoked by extracellularly applied Abeta: transgenic rats overexpressing Abeta intraneuronally display elevated levels of phosphorylated ERK2 (Echeverria et al., 2004), as do rat hippocampal slices in response to bath-applied Abeta (Dineley et al., 2001). Again, bath-applied Abeta causes an increase in BAX and a decrease in BCL2 expression in neurons or neuronlike cell lines (Koriyama et al., 2003; Clementi et al., 2006).

Related Edges 2

• a(CHEBI:"amyloid-beta") increases p(HGNC:MAPK1, pmod(Ph))
• a(CHEBI:"amyloid-beta") increases p(HGNC:BAX)

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