p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))

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PubMed:27373205

Highlighting the relevance of these findings to human disease, pS422 tau was found to colocalize with tau oligomers and with a fraction of tau showing increased PAD exposure in the human AD brain. This study identifies novel effects of pS422 on tau biochemical properties, including prolonged nucleation and enhanced dimer formation, which correlate with a distinct inhibitory effect on FAT.

Related Edges 4

• p(HBP:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
• p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"phosphatase-activating domain")
• p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau dimers")
• p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases bp(GO:"anterograde axonal transport")

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