path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")

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PubMed:24590577

The third important hallmark of AD is cholinergic hypofunction. The neurotransmitter acetylcholine (ACh) exerts its physiological functions by activating either ionotropic nicotinic ACh receptors (nAChRs) or metabotropic muscarinic ACh receptors (mAChRs). It has been reported that in AD brains there are (1) reduced choline acetyltransferase levels accompanied by decreased ACh synthesis; (2) significant loss of cholinergic neurons; (3) reduction in the numbers of postsynaptic neurons accessible to ACh; (4) cholinergic neuronal and axonal abnormalities; and (5) reduction in nAChR levels

Related Edges 6

• a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits"))
• a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic"))
• p(HGNC:CHAT) decreases a(CHEBI:acetylcholine)
• path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons")
• path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic")
• path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT)

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