PubMed: 21131359

Title
Nuclear tau, a key player in neuronal DNA protection.
Journal
The Journal of biological chemistry
Volume
286
Issue
None
Pages
4566-75
Date
2011-02-11
Authors
Buée L | Sultan A | Galas MC | Bonnefoy E | Bégard S | Colin M | Humez S | Loyens A | Mansuroglu Z | Marzin D | Nesslany F | Sergeant N | Talahari S | Violet M

Evidence e4fe78ee9f

In this work, we demonstrate that acute oxidative stress and mild heat stress (HS) induce the accumulation of dephosphorylated Tau in neuronal nuclei. Using chromatin immunoprecipitation assays, we demonstrate that the capacity of endogenous Tau to interact with neuronal DNA increased following HS. Comet assays performed on both wildtype and Tau-deficient neuronal cultures showed that Tau fully protected neuronal genomic DNA against HS-induced damage. Interestingly, HS-induced DNA damage observed in Tau-deficient cells was completely rescued after the overexpression of human Tau targeted to the nucleus.

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