Title

Calmodulin binds to a tubulin binding site of the microtubule-associated protein tau.

Journal

Molecular and cellular biochemistry

Volume

97

Issue

None

Pages

35-41

Date

1990-09-03

Authors

Padilla R | Maccioni RB | Avila J

These findings provide new insights into the regulation of microtubule assembly, since Ca2+/calmodulin inhibition of tubulin polymerization into microtubules could be mediated by the direct binding of calmodulin to tau, thus preventing the interaction of this latter protein with tubulin.

The present studies show that the calcium-binding protein calmodulin interacts with a tubulin binding site on tau defined by the second repetitive sequence

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