Title

The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.

Journal

PLoS genetics

Volume

10

Issue

None

Pages

e1004803

Date

2014-12-01

Authors

Bird TD | Ghetti B | Greenup L | Kraemer BC | Leverenz JB | Liachko NF | Loomis E | McMillan PJ | Montine TJ | Murrell JR | Raskind MA | Strovas TJ

Using refined methodology, we demonstrate TTBK1 and TTBK2 directly phosphorylate TDP-43 in vitro and promote TDP-43 phosphorylation in mammalian cultured cells. TTBK1/2 overexpression drives phosphorylation and relocalization of TDP-43 from the nucleus to cytoplasmic inclusions reminiscent of neuropathologic changes in disease states.

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