Title

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy.

Journal

Acta neuropathologica

Volume

126

Issue

None

Pages

809-27

Date

2013-12-01

Authors

Bailey RM | Covy JP | Dickson DW | Farrer MJ | Giasson BI | Knight J | Lewis J | Melrose HL | Miles S | Rousseau L | Watkinson R

Using mass spectrometry, we identified multiple sites on recombinant tau that are phosphorylated by LRRK2 in vitro, including pT149 and pT153, which are phospho-epitopes that to date have been largely unexplored. Importantly, we demonstrate that expression of transgenic LRRK2 in a mouse model of tauopathy increased the aggregation of insoluble tau and its phosphorylation at T149, T153, T205, and S199/S202/T205 epitopes.

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