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PubMed: 27133022

Title
Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites.
Journal
Structure (London, England : 1993)
Volume
24
Issue
None
Pages
851-61
Date
2016-06-07
Authors
Schultz C | Simon B | Wilmanns M | Hart DJ | Hoffmann JE | Huart AS | Komadina D | Kursula P | McCarthy AA | Mertens HD | Svergun DI | Temmerman K | Vahokoski J | Yumerefendi H

Evidence 8157599e02
JSON

Unexpectedly, impairment of the basic loop interaction site completely abolishes calcium/calmodulin binding and DAPK2 activity is reduced to a residual level, indicative of coupled binding to the two sites.

act(p(FPLX:CALM)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") View Subject | View Object

Appears in Networks:

act(p(FPLX:CALM)) increases act(p(HGNC:DAPK2)) View Subject | View Object

Appears in Networks:

p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2)) View Subject | View Object

Appears in Networks:

p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(FPLX:CALM)) View Subject | View Object

Appears in Networks:

act(p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") View Subject | View Object

Appears in Networks:

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