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PubMed: 26940749

Title
Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo.
Journal
Scientific reports
Volume
6
Issue
None
Pages
22685
Date
2016-03-04
Authors
Burnouf S | Dols J | Gorsky MK | Mandelkow E | Partridge L

Evidence fbe5fba920
JSON

hTau-K280Q mutants showed significantly increased phosphorylation on S262 as compared to both hTau-wt and hTau-K280R flies, when normalised to total hTau (K9JA) levels (**p < 0.01, one-way ANOVA, Fig. 4b,c). Mis-expression of pseudo-acetylated K280Q-hTau in the adult fly nervous system potently exacerbated fly locomotion defects and photoreceptor neurodegeneration.

p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) View Subject | View Object

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p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases a(HBP:Neurodegeneration) View Subject | View Object

Appears in Networks:

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