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PubMed: 24406748

Title
Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.
Journal
Neuroscience research
Volume
80
Issue
None
Pages
76-85
Date
2014-03-01
Authors
Hattori M | Horiguchi T | Iwashita H | Matsumoto Y | Nakamura K | Obayashi Y | Onishi T | Yano T

Evidence 770937dadc
JSON

We developed a transgenic mouse, named TPR50, harboring human P301S tau. Tau phosphorylation in the hippocampus of TPR50 mice increased with age, particularly at S202/T205. Therefore, cognitive dysfunction in TPR50 mice may result from early MT dysfunction and impaired axonal transport rather than accumulation of insoluble tau and neurodegeneration.

p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition) View Subject | View Object

Appears in Networks:

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