1. Catalog
  2. Citations
  3. PubMed:11089576

PubMed: 11089576

Title
Transglutaminase-induced cross-linking of tau proteins in progressive supranuclear palsy.
Journal
Journal of neuropathology and experimental neurology
Volume
59
Issue
None
Pages
983-9
Date
2000-11-01
Authors
Lee JM | Muma NA | Troncoso JC | Zemaitaitis MO

Evidence 2d68fbdba6
JSON

There were significantly higher levels of epsilon-(gamma-glutamyl) lysine cross-linking of PHF-tau in globus pallidus and pons regions of PSP cases compared to barely detectable cross-links in controls. The occipital cortex, an area spared from neurofibrillary pathology in PSP, showed no detectable cross-linking of PHF-tau protein in either PSP cases or control cases. Double-label immunofluorescence demonstrated the colocalization of the cross-link and PHF-tau in NFT in pons of PSP Previous studies and present data are consistent with the hypothesis that transglutaminase-induced cross-linking may be a factor contributing to the abnormal polymerization and stabilization of tau in straight and PHFs leading to neurofibrillary tangle formation in neurodegenerative diseases, including PSP and AD.

a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
globus pallidus
Uberon
pons

act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") View Subject | View Object

Appears in Networks:
Annotations
Uberon
globus pallidus
Uberon
pons

act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:
Annotations
Uberon
globus pallidus
Uberon
pons

path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:"2.3.2.13")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
globus pallidus
Uberon
pons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.