Title

Modulation of inducible nitric oxide synthase expression by sumoylation.

Journal

Journal of neuroinflammation

Volume

6

Issue

None

Pages

12

Date

2009-03-26

Authors

Akar CA | Feinstein DL

Noradrenaline (NA) attenuated the LPS-induced reductions and increased SUMO-1 above basal levels. Over-expression of SUMO-1, Ubc9, or SENP1 reduced the activation of a NOS2 promoter, whereas activation of a 4 x NFkappaB binding-element reporter was only reduced by SUMO-1. ChIP studies revealed interactions of SUMO-1 and C/EBPbeta with C/EBP binding sites on the NOS2 promoter that were modulated by LPS and NA. SUMO-1 co-precipitated with C/EBPbeta confirmed by FRET analysis

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