1. Catalog
  2. Citations
  3. PubMed:28250274

PubMed: 28250274

Title
Neprilysin Is Suppressed by Dual-Specificity Tyrosine-Phosphorylation Regulated Kinase 1A (DYRK1A) in Down-Syndrome-Derived Fibroblasts.
Journal
Biological & pharmaceutical bulletin
Volume
40
Issue
None
Pages
327-333
Date
2017-01-01
Authors
Asai M | Iwata N | Kawakubo T | Mori R | Shirotani K

Evidence c2891c1a17
JSON

Neprilysin, a major Aß-degrading enzyme, was downregulated in DS patient-derived fibroblasts. Treatment with harmine, a DYRK1A inhibitor and gene knockdown of DYRK1A, upregulated neprilysin in fibroblasts.

a(CHEBI:harmine) decreases p(HGNC:DYRK1A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Down Syndrome

a(CHEBI:harmine) increases p(HGNC:MME) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Down Syndrome

p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Down Syndrome

p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Down Syndrome

p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Down Syndrome

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.