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PubMed: 28002468

Title
Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.
Journal
PloS one
Volume
11
Issue
None
Pages
e0168913
Date
2016-01-01
Authors
Cohen TJ | Friedmann D | Hwang AW | Lee VM | Marmorstein R | Trzeciakiewicz H | Yuan CX

Evidence 0bb9c17fad
JSON

Similar to tau, MAP2 acetylation can occur in a cysteine-dependent auto-regulatory manner in the presence of acetyl-CoA. Tubulin reduced MAP2 acetylation, suggesting tubulin binding dictates MAP acetylation status.

a(CHEBI:"acetyl-CoA") increases a(HBP:"cystein-dependent auto-acetylation") View Subject | View Object

Appears in Networks:

a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAPT, pmod(Ac)) View Subject | View Object

Appears in Networks:

a(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(Ac)) View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.