1. Catalog
  2. Citations
  3. PubMed:18467332

PubMed: 18467332

Title
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.
Journal
The Journal of biological chemistry
Volume
283
Issue
None
Pages
18177-86
Date
2008-06-27
Authors
Zvelebil M | Kellie S | Varndell IM | Reynolds CH | Yang A | Garwood CJ | Perera T | Hanger DP | Price C | Sheppard PW | Anderton BH | Wray S

Evidence c241fc97db
JSON

As shown in Fig. 2A, tau co-sedimented with SH3 domains of cSrc, PLCgamma1, the N-terminal SH3 domain of Grb2, and most effectively with the p85alpha regulatory subunit of phosphatidylinositol 3-kinase.

p(HGNC:MAPT) association p(HGNC:SRC, frag("84_145")) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) association p(HGNC:PLCG1, frag("790_851")) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) association p(HGNC:GRB2, frag("1_57")) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) association complex(p(HGNC:GRB2), p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) association p(HGNC:PIK3R1, frag("3_79")) View Subject | View Object

Appears in Networks:

complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

Evidence a335fbf9ee
JSON

The binding of all four SH3 domains tested (from Fyn, p85alpha, PLCgamma1, and the N-terminal SH3 of Grb2) was considerably decreased by phosphorylation.

p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:SRC)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PLCG1)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:GRB2), p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.