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Entity

Name
Leukopenia
Namespace
MESHD
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mesh-diseases/mesh-diseases-20170511.belns

Appears in Networks 8

Colorectal Cancer Knowledge Assembly - Drugs Pathways and General Biology v1.1.0

Colorectal Cancer Knowledge Assembly with drug associations and Pathways + general CRC biology

Colorectal Cancer Knowledge Assembly - Drugs Pathways v1.0.0

Colorectal Cancer Knowledge Assembly with drug associations and Pathways.

Colorectal Cancer Model v2.0.0

Colorectal Cancer Model

Colorectal Cancer Model v0.0.0

Colorectal Cancer Model

Colorectal Cancer Model v2.0.3

Colorectal Cancer Model

Colorectal Cancer Model v2.0.4

Colorectal Cancer Model, uploaded by reagon

Colorectal Cancer Model v2.0.5

Colorectal Cancer Model, uploaded by reagon

Colorectal Cancer Model v2.0.6

Colorectal Cancer Model, uploaded by reagon

In-Edges 13

a(CHEBI:irinotecan) positiveCorrelation path(MESHD:Leukopenia)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

bp(MESHPP:Fasting) negativeCorrelation path(MESHD:Leukopenia)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Experimental Factor Ontology (EFO)
LS174T
MeSH
Intracellular Space
MeSH
Neoplasm Metastasis
MeSH
Peritoneum
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

composite(a(CHEBI:irinotecan), a(SCHEM:"5-fluorouracil"), a(SCHEM:Bevacizumab), a(SCHEM:Leucovorin)) association path(MESHD:Leukopenia)

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

Annotations
Experimental Factor Ontology (EFO)
LS174T
MeSH
Intracellular Space
MeSH
Neoplasm Metastasis
MeSH
Plasma
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

a(CHEBI:irinotecan) association path(MESHD:Leukopenia)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Experimental Factor Ontology (EFO)
LS174T
MeSH
Intracellular Space
MeSH
Neoplasm Metastasis
MeSH
Peritoneum
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

composite(a(SCHEM:"5-fluorouracil"), a(SCHEM:Bevacizumab), a(SCHEM:Leucovorin), a(SCHEM:Oxaliplatin)) association path(MESHD:Leukopenia)

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

Annotations
Experimental Factor Ontology (EFO)
LS174T
MeSH
Intracellular Space
MeSH
Neoplasm Metastasis
MeSH
Plasma
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

bp(MESHPP:Fasting) negativeCorrelation path(MESHD:Leukopenia)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10090

composite(a(CHEBI:irinotecan), a(SCHEM:"5-fluorouracil"), a(SCHEM:Bevacizumab), a(SCHEM:Leucovorin)) association path(MESHD:Leukopenia)

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

a(CHEBI:irinotecan) association path(MESHD:Leukopenia)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10090

composite(a(SCHEM:"5-fluorouracil"), a(SCHEM:Bevacizumab), a(SCHEM:Leucovorin), a(SCHEM:Oxaliplatin)) association path(MESHD:Leukopenia)

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

composite(a(CHEBI:"5-fluorouracil"), a(CHEBI:"5-formyltetrahydrofolic acid"), a(CHEBI:oxaliplatin), a(MeSH:Bevacizumab)) association path(MESHD:Leukopenia)

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:Fasting) negativeCorrelation path(MESHD:Leukopenia)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10090

a(CHEBI:irinotecan) association path(MESHD:Leukopenia)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10090

composite(a(CHEBI:"5-fluorouracil"), a(CHEBI:"5-formyltetrahydrofolic acid"), a(CHEBI:irinotecan), a(MeSH:Bevacizumab)) association path(MESHD:Leukopenia)

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

Annotations
Disease Ontology (DO)
colorectal cancer

Out-Edges 13

path(MESHD:Leukopenia) positiveCorrelation a(CHEBI:irinotecan)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

path(MESHD:Leukopenia) association composite(a(CHEBI:irinotecan), a(SCHEM:"5-fluorouracil"), a(SCHEM:Bevacizumab), a(SCHEM:Leucovorin))

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

Annotations
Experimental Factor Ontology (EFO)
LS174T
MeSH
Intracellular Space
MeSH
Neoplasm Metastasis
MeSH
Plasma
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

path(MESHD:Leukopenia) association a(CHEBI:irinotecan)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Experimental Factor Ontology (EFO)
LS174T
MeSH
Intracellular Space
MeSH
Neoplasm Metastasis
MeSH
Peritoneum
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

path(MESHD:Leukopenia) negativeCorrelation bp(MESHPP:Fasting)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Experimental Factor Ontology (EFO)
LS174T
MeSH
Intracellular Space
MeSH
Neoplasm Metastasis
MeSH
Peritoneum
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

path(MESHD:Leukopenia) association composite(a(SCHEM:"5-fluorouracil"), a(SCHEM:Bevacizumab), a(SCHEM:Leucovorin), a(SCHEM:Oxaliplatin))

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

Annotations
Experimental Factor Ontology (EFO)
LS174T
MeSH
Intracellular Space
MeSH
Neoplasm Metastasis
MeSH
Plasma
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

path(MESHD:Leukopenia) association composite(a(CHEBI:irinotecan), a(SCHEM:"5-fluorouracil"), a(SCHEM:Bevacizumab), a(SCHEM:Leucovorin))

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

path(MESHD:Leukopenia) association a(CHEBI:irinotecan)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10090

path(MESHD:Leukopenia) negativeCorrelation bp(MESHPP:Fasting)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10090

path(MESHD:Leukopenia) association composite(a(SCHEM:"5-fluorouracil"), a(SCHEM:Bevacizumab), a(SCHEM:Leucovorin), a(SCHEM:Oxaliplatin))

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

path(MESHD:Leukopenia) association a(CHEBI:irinotecan)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10090

path(MESHD:Leukopenia) association composite(a(CHEBI:"5-fluorouracil"), a(CHEBI:"5-formyltetrahydrofolic acid"), a(CHEBI:irinotecan), a(MeSH:Bevacizumab))

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

Annotations
Disease Ontology (DO)
colorectal cancer

path(MESHD:Leukopenia) negativeCorrelation bp(MESHPP:Fasting)

Ad libitum fed animals developed leucopenia compared with untreated controls, whereas fasted mice did not. PubMed:26332723

Annotations
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10090

path(MESHD:Leukopenia) association composite(a(CHEBI:"5-fluorouracil"), a(CHEBI:"5-formyltetrahydrofolic acid"), a(CHEBI:oxaliplatin), a(MeSH:Bevacizumab))

Regarding toxicity, the commonest grade 3-4 hematological adverse events were neutropenia (34.6 %) and leukopenia (7.7 %), and the commonest grade 3-4 non-hematological adverse events were anorexia (13.5 %), fatigue (9.6 %), nausea (9.6 %), and vomiting (9.6 %). Bevacizumab-related grade 3-4 adverse events included hypertension (1.9 %) and thrombosis (1.9 %). PubMed:26037783

Annotations
Disease Ontology (DO)
colorectal cancer

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