Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Melanoma
Namespace
MESHD
Namespace Version
20170725
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mesh-diseases/mesh-diseases-20170725.belns

Appears in Networks 21

Anhedonia_Model_Deliverable_1.3 v0.1.3

Anhedonia Model with 110 new articles (including 5 full texts) from Klaus until 9th March

BEL Framework Small Corpus Document v20150611

Approximately 2000 hand curated statements drawn from 57 PubMeds.

Anhedonia_Model_Deliverable_1.3 v0.2.4

Anhedonia Model Complete coding until 14th of May.

Anhedonia_Model_Deliverable_1.3 v0.2.5

Anhedonia Model Complete coding until 14th of May.

Anhedonia_Model_Deliverable_1.3 v0.2.6

Anhedonia Model Complete coding until 14th of May.

Anhedonia_Model_Deliverable_1.3 v0.2.0

Anhedonia Model Complete coding until 14th of May.

Colorectal Cancer Knowledge Assembly - Drugs Pathways and General Biology v1.1.0

Colorectal Cancer Knowledge Assembly with drug associations and Pathways + general CRC biology

Anhedonia_Model_Final v1.0.1

Anhedonia Model Complete coding until 14th of May.

Anhedonia_Model_Final v1.0.2

Anhedonia Model Complete coding generated from an equivalent of 421 articles (321 abstracts+10 full text (*10 abstracts)). It also contains part of projection models, since all the statements with non projection information discarded from projection model.

colorectal cancer Knowledge Assembly - Drugs v1.0.1

colorectal cancer Knowledge Assembly with drug associations.

Colorectal Cancer Model v1.0.0

Colorectal Cancer Model built for i:DSem-BMBF project.

colorectal cancer Drugs resistance v1.0.1.0

colorectal cancer Knowledge Assembly with drug associations.

CRC_combined v1.1

BEL Document

Colorectal Cancer Model v2.0.0

Colorectal Cancer Model

Colorectal Cancer Model v0.0.0

Colorectal Cancer Model

Colorectal Cancer Model v2.0.3

Colorectal Cancer Model

Colorectal Cancer Model v2.0.4

Colorectal Cancer Model, uploaded by reagon

Colorectal Cancer Model v2.0.5

Colorectal Cancer Model, uploaded by reagon

Colorectal Cancer Model v2.0.6

Colorectal Cancer Model, uploaded by reagon

In-Edges 18

act(p(HGNC:BRAF), ma(kin)) positiveCorrelation path(MESHD:Melanoma)

Somatic B-raf mutations were demonstrated in 60% to 70% of malignant melanomas and in moderate to high rates in carcinomas of the colon, ovary, and thyroid (papillary), implicating activating oncogenic B-raf mutations as critical promoters of these malignancies.9,14-17 PubMed:16170185

Annotations
Experimental Factor Ontology (EFO)
U-937 cell
NCBI Taxonomy Ids
9606
Uberon
cardiovascular system endothelium
Cell Ontology (CL)
fibroblast
MeSH
Cytoplasm
Disease Ontology (DO)
cancer
MeSH
Muscle, Smooth, Vascular

p(HGNC:NRAS, var(p.Gln61Arg)) association path(MESHD:Melanoma)

Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma.Thirty-five cases harbored the NRASQ61R mutation (19 malignant melanomas, one melanocytic nevus, 10 thyroid carcinomas, two gastrointestinal carcinomas, and three other malignancies). PubMed:26712868

p(HGNC:MAPK3) association path(MESHD:Melanoma)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HT-29
MeSH
Melanoma
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Serum
NCBI Taxonomy Names
Homo sapiens
NCBI Taxonomy Ids
10117

p(HGNC:CSE1L) association path(MESHD:Melanoma)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HT-29
MeSH
Melanoma
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Serum
NCBI Taxonomy Names
Homo sapiens
NCBI Taxonomy Ids
10117

p(MGI:Braf) negativeCorrelation path(MESHD:Melanoma)

Indeed, recent clinical trials involving B-Raf selective inhibitors exhibited unprecedented response rates in metastatic melanoma patients. PubMed:22471666

Annotations
MeSH
Chromatin
Experimental Factor Ontology (EFO)
cancer cell line
MeSH
Melanoma
Evidence and Conclusion Ontology
MTT assay
MeSH
Colon
NCBI Taxonomy Names
Homo sapiens
NCBI Taxonomy Ids
10117

p(HGNC:BRAF) association path(MESHD:Melanoma)

Signatures for BRAF oncogene have been revealed in melanoma. PubMed:22515520

Annotations
NCBI Taxonomy Ids
9606
Experimental Factor Ontology (EFO)
SW480
Disease Ontology (DO)
colorectal cancer
MeSH
Neoplasms

p(HGNC:BRAF) association path(MESHD:Melanoma)

Signatures for BRAF oncogene have been revealed in melanoma. PubMed:22515520

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
SW480
MeSH
Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Plasma
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
9606

p(HGNC:NRAS, var(p.Gln61Arg)) association path(MESHD:Melanoma)

Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma.Thirty-five cases harbored the NRASQ61R mutation (19 malignant melanomas, one melanocytic nevus, 10 thyroid carcinomas, two gastrointestinal carcinomas, and three other malignancies). PubMed:26712868

p(HGNC:NRAS, var(p.Gln61Arg)) association path(MESHD:Melanoma)

Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma.Thirty-five cases harbored the NRASQ61R mutation (19 malignant melanomas, one melanocytic nevus, 10 thyroid carcinomas, two gastrointestinal carcinomas, and three other malignancies). PubMed:26712868

Appears in Networks:
Annotations
MeSH
Condylomata Acuminata
Evidence and Conclusion Ontology
immunohistochemistry
NCBI Taxonomy Names
Mus musculus

p(HGNC:BRAF) association path(MESHD:Melanoma)

Signatures for BRAF oncogene have been revealed in melanoma. PubMed:22515520

Annotations
Experimental Factor Ontology (EFO)
SW480
MeSH
Intracellular Space
MeSH
Neoplasms
MeSH
Mucus
NCBI Taxonomy Names
Crataegus azarolus
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:CSE1L) association path(MESHD:Melanoma)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Annotations
Experimental Factor Ontology (EFO)
HT-29
MeSH
Chromatin
MeSH
Melanoma
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
RNAi
MeSH
Serum
NCBI Taxonomy Names
Homo sapiens
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

p(HGNC:NRAS, var(p.Gln61Arg)) association path(MESHD:Melanoma)

Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma.Thirty-five cases harbored the NRASQ61R mutation (19 malignant melanomas, one melanocytic nevus, 10 thyroid carcinomas, two gastrointestinal carcinomas, and three other malignancies). PubMed:26712868

p(MGI:Braf) negativeCorrelation path(MESHD:Melanoma)

Indeed, recent clinical trials involving B-Raf selective inhibitors exhibited unprecedented response rates in metastatic melanoma patients. PubMed:22471666

Annotations
Experimental Factor Ontology (EFO)
HCT116
MeSH
Peroxisomes
MeSH
Melanoma
Evidence and Conclusion Ontology
gain_of_function mutant phenotype
MeSH
Blood Platelets
MeSH
Endothelium, Vascular
NCBI Taxonomy Names
Homo sapiens
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

p(HGNC:MAPK3) association path(MESHD:Melanoma)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Annotations
Experimental Factor Ontology (EFO)
HT-29
MeSH
Chromatin
MeSH
Melanoma
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
RNAi
MeSH
Serum
NCBI Taxonomy Names
Homo sapiens
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

p(HGNC:CSE1L) association path(MESHD:Melanoma)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

p(MGI:Braf) negativeCorrelation path(MESHD:Melanoma)

Indeed, recent clinical trials involving B-Raf selective inhibitors exhibited unprecedented response rates in metastatic melanoma patients. PubMed:22471666

p(HGNC:MAPK3) association path(MESHD:Melanoma)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Out-Edges 26

path(MESHD:Melanoma) increases r(MGI:Il6)

Similarly, a high level of tumor development produced increases in the brain expression levels of IL-6 and TNF-α and plasma levels of IL-6. PubMed:24995613

path(MESHD:Melanoma) increases r(MGI:Il6)

Similarly, a high level of tumor development produced increases in the brain expression levels of IL-6 and TNF-α and plasma levels of IL-6. PubMed:24995613

Annotations
NCBI Taxonomy Ids
10090
Anhedonia_Model_Deliverable_1.2
plasma

path(MESHD:Melanoma) increases r(MGI:Tnf)

Similarly, a high level of tumor development produced increases in the brain expression levels of IL-6 and TNF-α and plasma levels of IL-6. PubMed:24995613

path(MESHD:Melanoma) positiveCorrelation act(p(HGNC:BRAF), ma(kin))

Somatic B-raf mutations were demonstrated in 60% to 70% of malignant melanomas and in moderate to high rates in carcinomas of the colon, ovary, and thyroid (papillary), implicating activating oncogenic B-raf mutations as critical promoters of these malignancies.9,14-17 PubMed:16170185

Annotations
Experimental Factor Ontology (EFO)
U-937 cell
NCBI Taxonomy Ids
9606
Uberon
cardiovascular system endothelium
Cell Ontology (CL)
fibroblast
MeSH
Cytoplasm
Disease Ontology (DO)
cancer
MeSH
Muscle, Smooth, Vascular

path(MESHD:Melanoma) increases r(MGI:Il6)

Similarly, a high level of tumor development produced increases in the brain expression levels of IL-6 and TNF-α and plasma levels of IL-6. PubMed:24995613

path(MESHD:Melanoma) association p(HGNC:NRAS, var(p.Gln61Arg))

Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma.Thirty-five cases harbored the NRASQ61R mutation (19 malignant melanomas, one melanocytic nevus, 10 thyroid carcinomas, two gastrointestinal carcinomas, and three other malignancies). PubMed:26712868

path(MESHD:Melanoma) association p(HGNC:CSE1L)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HT-29
MeSH
Melanoma
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Serum
NCBI Taxonomy Names
Homo sapiens
NCBI Taxonomy Ids
10117

path(MESHD:Melanoma) association p(HGNC:MAPK3)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HT-29
MeSH
Melanoma
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Serum
NCBI Taxonomy Names
Homo sapiens
NCBI Taxonomy Ids
10117

path(MESHD:Melanoma) negativeCorrelation p(MGI:Braf)

Indeed, recent clinical trials involving B-Raf selective inhibitors exhibited unprecedented response rates in metastatic melanoma patients. PubMed:22471666

Annotations
MeSH
Chromatin
Experimental Factor Ontology (EFO)
cancer cell line
MeSH
Melanoma
Evidence and Conclusion Ontology
MTT assay
MeSH
Colon
NCBI Taxonomy Names
Homo sapiens
NCBI Taxonomy Ids
10117

path(MESHD:Melanoma) association p(HGNC:BRAF)

Signatures for BRAF oncogene have been revealed in melanoma. PubMed:22515520

Annotations
NCBI Taxonomy Ids
9606
Experimental Factor Ontology (EFO)
SW480
Disease Ontology (DO)
colorectal cancer
MeSH
Neoplasms

path(MESHD:Melanoma) association p(HGNC:BRAF)

Signatures for BRAF oncogene have been revealed in melanoma. PubMed:22515520

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
SW480
MeSH
Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Plasma
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
9606

path(MESHD:Melanoma) association p(HGNC:NRAS, var(p.Gln61Arg))

Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma.Thirty-five cases harbored the NRASQ61R mutation (19 malignant melanomas, one melanocytic nevus, 10 thyroid carcinomas, two gastrointestinal carcinomas, and three other malignancies). PubMed:26712868

path(MESHD:Melanoma) association p(HGNC:NRAS, var(p.Gln61Arg))

Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma.Thirty-five cases harbored the NRASQ61R mutation (19 malignant melanomas, one melanocytic nevus, 10 thyroid carcinomas, two gastrointestinal carcinomas, and three other malignancies). PubMed:26712868

Appears in Networks:
Annotations
MeSH
Condylomata Acuminata
Evidence and Conclusion Ontology
immunohistochemistry
NCBI Taxonomy Names
Mus musculus

path(MESHD:Melanoma) negativeCorrelation p(MGI:Braf)

Indeed, recent clinical trials involving B-Raf selective inhibitors exhibited unprecedented response rates in metastatic melanoma patients. PubMed:22471666

Annotations
Experimental Factor Ontology (EFO)
HCT116
MeSH
Peroxisomes
MeSH
Melanoma
Evidence and Conclusion Ontology
gain_of_function mutant phenotype
MeSH
Blood Platelets
MeSH
Endothelium, Vascular
NCBI Taxonomy Names
Homo sapiens
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

path(MESHD:Melanoma) association p(HGNC:NRAS, var(p.Gln61Arg))

Testing for NRAS mutation at codon Q61 is of therapeutic, prognostic, and diagnostic importance for metastatic melanoma, thyroid carcinoma, and colorectal carcinoma.Thirty-five cases harbored the NRASQ61R mutation (19 malignant melanomas, one melanocytic nevus, 10 thyroid carcinomas, two gastrointestinal carcinomas, and three other malignancies). PubMed:26712868

path(MESHD:Melanoma) association p(HGNC:BRAF)

Signatures for BRAF oncogene have been revealed in melanoma. PubMed:22515520

Annotations
Experimental Factor Ontology (EFO)
SW480
MeSH
Intracellular Space
MeSH
Neoplasms
MeSH
Mucus
NCBI Taxonomy Names
Crataegus azarolus
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

path(MESHD:Melanoma) association p(HGNC:MAPK3)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Annotations
Experimental Factor Ontology (EFO)
HT-29
MeSH
Chromatin
MeSH
Melanoma
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
RNAi
MeSH
Serum
NCBI Taxonomy Names
Homo sapiens
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

path(MESHD:Melanoma) association p(HGNC:CSE1L)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

Annotations
Experimental Factor Ontology (EFO)
HT-29
MeSH
Chromatin
MeSH
Melanoma
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
RNAi
MeSH
Serum
NCBI Taxonomy Names
Homo sapiens
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
10090

path(MESHD:Melanoma) negativeCorrelation p(MGI:Braf)

Indeed, recent clinical trials involving B-Raf selective inhibitors exhibited unprecedented response rates in metastatic melanoma patients. PubMed:22471666

path(MESHD:Melanoma) association p(HGNC:MAPK3)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

path(MESHD:Melanoma) association p(HGNC:CSE1L)

Vemurafenib and sorafenib treatment did not significantly reduce the total CSE1L levels; however, they inhibited ERK1/2 and CSE1L phosphorylation in A375 melanoma cells and HT-29 colorectal cancer cells. PubMed:26070816

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.