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Entity

Name
Antibody-Dependent Cell Cytotoxicity
Namespace
MESHPP
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mesh-processes/mesh-processes-20170511.belns

Appears in Networks 10

Colorectal Cancer Knowledge Assembly - Drugs Pathways and General Biology v1.1.0

Colorectal Cancer Knowledge Assembly with drug associations and Pathways + general CRC biology

Colorectal Cancer Knowledge Assembly - Drugs Pathways v1.0.0

Colorectal Cancer Knowledge Assembly with drug associations and Pathways.

CRC_combined v1.1

BEL Document

Colorectal Cancer Model v2.0.0

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Colorectal Cancer Model

Colorectal Cancer Model v2.0.3

Colorectal Cancer Model

Colorectal Cancer Model v2.0.4

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Colorectal Cancer Model v2.0.5

Colorectal Cancer Model, uploaded by reagon

Colorectal Cancer Model v2.0.6

Colorectal Cancer Model, uploaded by reagon

In-Edges 74

g(HGNC:FCGR1CP) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2C) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR3B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR3A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2A, pmod(Hy, His, 131)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

p(HGNC:FCGR1A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2A, pmod(Hy, Arg, 131)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

p(HGNC:FCGRT) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR1B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGBP) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2A, pmod(Hy, His, 131)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR3A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR1B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR3B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR1A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR2A, pmod(Hy, Arg, 131)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGBP) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGRT) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR2A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR2B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR2C) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

p(HGNC:FCGR3A, var(p.Val158Phe)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR2A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGRT) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(SFAM:"CD32 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR2B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR2A, var(p.His131His)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGBP) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR2A, var(p.His131Arg)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(SFAM:"CD64 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR2C) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR3B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR3A, var(p.Val158Val)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR3A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR1B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

a(SCHEM:Cetuximab) increases bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Cetuximab is a monoclonal antibody to the EGFR that induces antibody-dependent cell cytotoxicity (ADCC) through Fcγ receptors on immune cells. PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR1A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(SFAM:"CD16 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

p(HGNC:FCGR3A, var(p.Val158Phe)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

p(HGNC:FCGR2A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGRT) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(SFAM:"CD32 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2A, var(p.His131His)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

p(HGNC:FCGBP) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2A, var(p.His131Arg)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

p(SFAM:"CD64 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR2C) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR3B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR3A, var(p.Val158Val)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

p(HGNC:FCGR3A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR1B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

a(SCHEM:Cetuximab) increases bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Cetuximab is a monoclonal antibody to the EGFR that induces antibody-dependent cell cytotoxicity (ADCC) through Fcγ receptors on immune cells. PubMed:26817995

p(HGNC:FCGR1A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(SFAM:"CD16 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

p(HGNC:FCGR3A, var(p.Val158Phe)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR2A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGRT) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(SFAM:"CD32 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR2B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR2A, var(p.His131His)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGBP) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR2A, var(p.His131Arg)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(SFAM:"CD64 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR2C) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR3B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR3A, var(p.Val158Val)) positiveCorrelation bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

a(MeSH:Cetuximab) increases bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

Cetuximab is a monoclonal antibody to the EGFR that induces antibody-dependent cell cytotoxicity (ADCC) through Fcγ receptors on immune cells. PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR3A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR1B) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(HGNC:FCGR1A) association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

p(SFAM:"CD16 Family") association bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

Out-Edges 71

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGRT)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, pmod(Hy, Arg, 131))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, pmod(Hy, His, 131))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGBP)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association g(HGNC:FCGR1CP)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2C)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, pmod(Hy, Arg, 131))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGRT)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, pmod(Hy, His, 131))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2C)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGBP)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
MeSH
Microtubules
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Colorectal Neoplasms
Evidence and Conclusion Ontology
immunohistochemistry
MeSH
Allografts
NCBI Taxonomy Names
Mus musculus
Disease Ontology (DO)
colorectal cancer
NCBI Taxonomy Ids
10117

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD16 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, var(p.His131Arg))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD64 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR3A, var(p.Val158Phe))

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2C)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD32 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGBP)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGRT)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR3A, var(p.Val158Val))

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, var(p.His131His))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
Experimental Factor Ontology (EFO)
HCT-15 cell
MeSH
Intracellular Space
MeSH
Condylomata Acuminata
MeSH
Mucus
NCBI Taxonomy Names
Atractylodes macrocephala
NCBI Taxonomy Names
Panax ginseng
NCBI Taxonomy Names
Astragalus membranaceus
NCBI Taxonomy Names
Glycyrrhiza uralensis
NCBI Taxonomy Names
Poria cocos
NCBI Taxonomy Names
Coix lacryma-jobi
Disease Ontology (DO)
colorectal cancer
Uberon
intestinal epithelium
Cell Ontology (CL)
stem cell
NCBI Taxonomy Ids
9606

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD16 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, var(p.His131Arg))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD64 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR3A, var(p.Val158Phe))

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2C)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD32 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGBP)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGRT)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR3A, var(p.Val158Val))

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, var(p.His131His))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD16 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, var(p.His131Arg))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD64 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR3A, var(p.Val158Phe))

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR2C)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(SFAM:"CD32 Family")

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR1A)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGBP)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGR3B)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") association p(HGNC:FCGRT)

SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR3A, var(p.Val158Val))

Patients carrying FcγRIIIa genotypes with the V alleles 158V/V and 158V/F displayed higher ADCC compared with patients carrying the 158F/F genotype (P= 0.001). PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

bp(MESHPP:"Antibody-Dependent Cell Cytotoxicity") positiveCorrelation p(HGNC:FCGR2A, var(p.His131His))

Patients carrying the FcγRIIa H alleles 131H/Hand 131H/R had significantly higher ADCC compared with patients with the 131R/R alleles (P= 0.013). PubMed:26817995

Annotations
Disease Ontology (DO)
colorectal cancer

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.