Provenance

Upload
justyna.szostak@pmi.com at 2020-02-04 19:04:09
Authors
Exported fromBel-C
Contact
J.szostak.com
Description
test BEl doc.
License
Test
Copyright
Copyright © 2018 CausalityBiomodels
Number Nodes
26
Number Edges
115
Number Components
2
Network Density
0.176923
Average Degree
4.42308
Number Citations
2
Number BEL Errors
64

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Exported from Bel-c 15.bel v2.0.4 100%
Exported from Bel-c1.bel v2.0.4 100%
BEL Framework Large Corpus Document v20170611 65%
Xenobiotic Metabolism Response-2.0-Mm v2.0 15%
Selventa Protein Families Definitions v20150611 8%
Xenobiotic Metabolism Response-2.0-Hs v2.0 4%
Cell Interaction-2.0-Mm v2.0 4%
Epithelial Mucus Hypersecretion-2.0-Mm v2.0 4%
Megakaryocyte Differentiation-2.0-Mm v2.0 4%
NFE2L2 Signaling-2.0-Mm v2.0 4%

Sample Edges

act(p(MGI:Rara)) decreases p(MGI:Cyp3a11)

APP did though potentiate both Wnt3a-driven Wnt-β-catenin signalling and Wnt5a-driven Wnt-PCP signalling. These findings confirm the previously reported involvement of APP in Wnt-PCP signalling, and identify a new role of APP in Wnt-β-catenin signalling. PubMed:30232325

act(p(MGI:Ahr)) increases r(MGI:Cyp1a1)

The gene encoding AhR, which regulates CYP1A1, CYP1A2, and CYP1B1, was also induced by rifampicin and PB (Table 4, line 12). PubMed:12181440

act(p(MGI:Ahr)) increases r(MGI:Cyp1b1)

The gene encoding AhR, which regulates CYP1A1, CYP1A2, and CYP1B1, was also induced by rifampicin and PB (Table 4, line 12). PubMed:12181440

act(p(MGI:Ahr)) increases r(MGI:Cyp1a2)

The gene encoding AhR, which regulates CYP1A1, CYP1A2, and CYP1B1, was also induced by rifampicin and PB (Table 4, line 12). PubMed:12181440

act(p(MGI:Nr1i3)) increases r(MGI:Cyp3a41a)

As expected, rifampicin and PB treatment resulted in the induction of CYP3A4 and CYP2B6 in both sets of cultured hepatocytes (Table 4, lines 6 and 7). PubMed:12181440

Sample Nodes

p(MGI:Abcb1a)

In-Edges: 4 | Out-Edges: 54 | Classes: 1 | Explore Neighborhood | Download JSON

r(MGI:Cyp1b1)

In-Edges: 7 | Out-Edges: 0 | Explore Neighborhood | Download JSON

p(MGI:Cyp3a11)

In-Edges: 4 | Out-Edges: 0 | Explore Neighborhood | Download JSON

r(MGI:Aldh1a7)

In-Edges: 3 | Out-Edges: 0 | Explore Neighborhood | Download JSON

r(MGI:Alas1)

In-Edges: 9 | Out-Edges: 0 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.