Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2019-02-05 12:11:01
Authors
Charles Tapley Hoyt
Contact
charles.hoyt@scai.fraunhofer.de
Description
A small assortment of academic articles describing quantitatively described interactions between the MAPT (Tau) protein and small molecules
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
23
Number Edges
23
Number Components
2
Network Density
0.0454545
Average Degree
1.0
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap

Sample Edges

a(HBP:HBP00021) decreases a(HBP:HBP00018)

Structures of Aβ-aggregation inhibitors evaluated in current or past clinical trials. PubMed:23484434

a(CHEBI:8028) causesNoChange a(HBP:HBP00006)

Redox cycling of methylene blue and TAGI potencies. Upper panel (black): Reduced leuco form 2 and structural overlap with inactive phenothiazines 3, 4, and 5. Lower panel (blue): Structural overlap between oxidized form 1 and azure A (6), reduced anthraquinone, 8, and 9, showing the extended π-conjugated system (ND: not determined). PubMed:23484434

a(CHEBI:4806) decreases a(HBP:HBP00006)

Pyrogallol generic substitution pattern commonly found in multiple polyphenolic Tau aggregation inhibitors such as 12 and 19. Note the structural overlap with the inactive pyrocatechol-substituted epicatechin PubMed:23484434

a(CHEBI:4806) decreases a(HBP:HBP00018)

Structures of Aβ-aggregation inhibitors evaluated in current or past clinical trials. PubMed:23484434

a(HBP:HBP00019) decreases a(HBP:HBP00018)

Structures of Aβ-aggregation inhibitors evaluated in current or past clinical trials. PubMed:23484434

Sample Nodes

a(CHEBI:4806)

In-Edges: 1 | Out-Edges: 3 | Explore Neighborhood | Download JSON

a(GO:"GO:0097418")

In-Edges: 2 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(HBP:HBP00006)

In-Edges: 15 | Out-Edges: 0 | Explore Neighborhood | Download JSON

a(HBP:HBP00021)

In-Edges: 0 | Out-Edges: 1 | Explore Neighborhood | Download JSON

a(CHEBI:8028)

In-Edges: 0 | Out-Edges: 1 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.