Table of Contents

Namespaces

Unused Namespaces 8

The source BEL script contained references to the following namespaces, but they were never used. It is suggested to delete their definitions from the BEL script to improve readability and parsing speed.

  • CHEBI
  • CHEMBLA
  • GOBP
  • GOCC
  • HGNC
  • MESHD
  • MGI
  • RGD

Annotations

This section lists all of the annotations that are defined in the original BEL script.

Keyword URL Stratify
Anatomy https://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno View Stratified Summary
Disease https://arty.scai.fraunhofer.de/artifactory/bel/annotation/disease/disease-20170511.belanno View Stratified Summary
MeSHAnatomy https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno View Stratified Summary
Species https://arty.scai.fraunhofer.de/artifactory/bel/annotation/species-taxonomy-id/species-taxonomy-id-20170511.belanno View Stratified Summary

Unused Annotations 9

The source BEL script contained references to the following annotations, but they were never used. It is suggested to delete their definitions from the BEL script to improve readability and parsing speed.

Note: this may be due to errors occurring in all statements with these annotations.

  • Anatomy
  • Assay
  • CellLine
  • Disease
  • Dosage
  • MeSHAnatomy
  • MouseStrain
  • Species
  • TextLocation

Locally Defined Annotations 5

The source BEL script contained annotations defined as a list. Click each link to export the list definition as a BELANNO file that can hosted externally to promote re-usability and interoperability. After, you can replace the list definition in the source BEL with a SET ANNOTATION X AS URL "Y" definition.

Unused Locally Defined Annotations 5

The source BEL script contained the following list annotations, but no references to the following values. It is suggested to prune these values from the list definitions.

Note: this may be due to errors occurring in all statements with these annotations.

Annotation Values
Assay
  • ELISA
  • Reporter Gene Assays
  • IHC
  • Multiplex Assay
CellLine
  • HEK293A
Dosage
  • 10 µM
MouseStrain
  • 3xTG-AD
TextLocation
  • Abstract
  • Result

Warning Statistics

Syntax Errors 2

Line BEL Message
73 bp(GOBP:"non-canonical Wnt signaling pathway"))->a(CHEBI:"amyloid-beta") General Parser Failure on line 73 at pos 46: bp(GOBP:"non-canonical Wnt signaling pathway"))->a(CHEBI:"amyloid-beta")
74 bp(GOBP:"canonical Wnt signaling pathway"))-|a(CHEBI:"amyloid-beta") General Parser Failure on line 74 at pos 42: bp(GOBP:"canonical Wnt signaling pathway"))-|a(CHEBI:"amyloid-beta")

All Parser Warnings 170

A faceted table view of all parser warnings can be viewed and exported from here.

Line BEL Message
39 SET Citation = {"Transl Psychiatry. 2018 Sep 20;8(1):179. doi: 10.1038/s41398-018-0231-6"} [pos:4] Citation is missing required fields: SET Citation = {"Transl Psychiatry. 2018 Sep 20;8(1):179. doi: 10.1038/s41398-018-0231-6"}
41 SET TextLocation = "Abstract" Missing citation; can't add: SET TextLocation = "Abstract"
43 SET Support = "In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling." Missing citation; can't add: SET Support = "In Alzheimer’s disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling."
47 SET Disease: "Alzheimer's disease" Missing citation; can't add: SET Disease: "Alzheimer's disease"
49 p(HGNC:DKK1)-| bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:DKK1)-| bp(GOBP:"canonical Wnt signaling pathway")
50 a(CHEBI:"amyloid-beta")->p(MGI:Dkk1) Missing citation; can't add: a(CHEBI:"amyloid-beta")->p(MGI:Dkk1)
51 p(HGNC:DKK1)->bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:DKK1)->bp(GOBP:"non-canonical Wnt signaling pathway")
52 a(CHEBI:"amyloid-beta")->bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: a(CHEBI:"amyloid-beta")->bp(GOBP:"non-canonical Wnt signaling pathway")
54 UNSET Disease: "Alzheimer's disease" Missing citation; can't add: UNSET Disease: "Alzheimer's disease"
56 SET Support = "Canonical (Wnt-β-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synapse retraction; thus Aβ-driven synapse loss is mediated by Dkk1. Here we show that the Amyloid Precursor Protein (APP) co-activates both arms of Wnt signalling through physical interactions with Wnt co-receptors LRP6 and Vangl2, to bi-directionally modulate synapse stability." Missing citation; can't add: SET Support = "Canonical (Wnt-β-catenin) signalling promotes synapse stability, while non-canonical (Wnt-PCP) signalling favours synapse retraction; thus Aβ-driven synapse loss is mediated by Dkk1. Here we show that the Amyloid Precursor Protein (APP) co-activates both arms of Wnt signalling through physical interactions with Wnt co-receptors LRP6 and Vangl2, to bi-directionally modulate synapse stability."
60 bp(GOBP:"canonical Wnt signaling pathway")-> bp("synapse stability") [pos:48] "synapse stability" should be qualified with a valid namespace
61 bp(GOBP:"non-canonical Wnt signaling pathway")->bp(GOBP:"synapse pruning") "synapse pruning" is not in the GOBP namespace
62 p(HGNC:DKK1)->bp(GOBP:"synapse pruning") "synapse pruning" is not in the GOBP namespace
63 complex(p(HGNC:APP),p(HGNC:LRP6))-> bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: complex(p(HGNC:APP),p(HGNC:LRP6))-> bp(GOBP:"canonical Wnt signaling pathway")
64 complex(p(HGNC:APP),p(HGNC:LRP6))-> bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: complex(p(HGNC:APP),p(HGNC:LRP6))-> bp(GOBP:"non-canonical Wnt signaling pathway")
65 complex(p(HGNC:APP),p(HGNC:VANGl2))-> bp(GOBP:"canonical Wnt signaling pathway") "VANGl2" is not in the HGNC namespace
66 complex(p(HGNC:APP),p(HGNC:VANGl2))-> bp(GOBP:"non-canonical Wnt signaling pathway") "VANGl2" is not in the HGNC namespace
68 SET Support = "Furthermore, activation of non-canonical Wnt signalling enhances Aβ production, while activation of canonical signalling suppresses Aβ production. Together, these findings identify a pathogenic-positive feedback loop in which Aβ induces Dkk1 expression, thereby activating non-canonical Wnt signalling to promote synapse loss and drive further Aβ production." Missing citation; can't add: SET Support = "Furthermore, activation of non-canonical Wnt signalling enhances Aβ production, while activation of canonical signalling suppresses Aβ production. Together, these findings identify a pathogenic-positive feedback loop in which Aβ induces Dkk1 expression, thereby activating non-canonical Wnt signalling to promote synapse loss and drive further Aβ production."
73 bp(GOBP:"non-canonical Wnt signaling pathway"))->a(CHEBI:"amyloid-beta") General Parser Failure on line 73 at pos 46: bp(GOBP:"non-canonical Wnt signaling pathway"))->a(CHEBI:"amyloid-beta")
74 bp(GOBP:"canonical Wnt signaling pathway"))-|a(CHEBI:"amyloid-beta") General Parser Failure on line 74 at pos 42: bp(GOBP:"canonical Wnt signaling pathway"))-|a(CHEBI:"amyloid-beta")
75 a(CHEBI:"amyloid-beta")->p(HGNC:DKK1) Missing citation; can't add: a(CHEBI:"amyloid-beta")->p(HGNC:DKK1)
76 a(CHEBI:"amyloid-beta")->bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: a(CHEBI:"amyloid-beta")->bp(GOBP:"non-canonical Wnt signaling pathway")
77 a(CHEBI:"amyloid-beta") pos bp(GOBP:"synapse pruning") "synapse pruning" is not in the GOBP namespace
78 bp(GOBP:"non-canonical Wnt signaling pathway") pos bp(GOBP:"synapse pruning") "synapse pruning" is not in the GOBP namespace
79 bp(GOBP:"synapse pruning")->a(CHEBI:"amyloid-beta") "synapse pruning" is not in the GOBP namespace
80 bp(GOBP:"non-canonical Wnt signaling pathway")->a(CHEBI:"amyloid-beta") Missing citation; can't add: bp(GOBP:"non-canonical Wnt signaling pathway")->a(CHEBI:"amyloid-beta")
83 SET Support = "The Swedish familial AD variant of APP (APPSwe) more readily co-activates non-canonical, at the expense of canonical Wnt activity, indicating that its pathogenicity likely involves direct effects on synapses, in addition to increased Aβ production." Missing citation; can't add: SET Support = "The Swedish familial AD variant of APP (APPSwe) more readily co-activates non-canonical, at the expense of canonical Wnt activity, indicating that its pathogenicity likely involves direct effects on synapses, in addition to increased Aβ production."
87 p(HGNC:APP,var("?"))-> bp(GOBP:"non-canonical Wnt signaling pathway")) Missing citation; can't add: p(HGNC:APP,var("?"))-> bp(GOBP:"non-canonical Wnt signaling pathway"))
88 p(HGNC:APP,var("?")) neg bp(GOBP:"canonical Wnt signaling pathway")) Missing citation; can't add: p(HGNC:APP,var("?")) neg bp(GOBP:"canonical Wnt signaling pathway"))
89 p(HGNC:APP,var("?")) pos a(GOCC:synapse) Missing citation; can't add: p(HGNC:APP,var("?")) pos a(GOCC:synapse)
90 p(HGNC:APP,var("?"))->a(CHEBI:"amyloid-beta") Missing citation; can't add: p(HGNC:APP,var("?"))->a(CHEBI:"amyloid-beta")
92 SET Support = "Finally, we report that pharmacological inhibition of the Aβ-Dkk1-Aβ positive feedback loop with the drug fasudil can restore the balance between Wnt pathways, prevent dendritic spine withdrawal in vitro, and reduce Aβ load in vivo in mice with advanced amyloid pathology. These results clarify a relationship between Aβ accumulation and synapse loss and provide direction for the development of potential disease-modifying treatments." Missing citation; can't add: SET Support = "Finally, we report that pharmacological inhibition of the Aβ-Dkk1-Aβ positive feedback loop with the drug fasudil can restore the balance between Wnt pathways, prevent dendritic spine withdrawal in vitro, and reduce Aβ load in vivo in mice with advanced amyloid pathology. These results clarify a relationship between Aβ accumulation and synapse loss and provide direction for the development of potential disease-modifying treatments."
97 SET Species = "Mus musculus" Missing citation; can't add: SET Species = "Mus musculus"
99 a(CHEMBLA:CHEMBL38380)-|a(CHEBI:"amyloid-beta") Missing citation; can't add: a(CHEMBLA:CHEMBL38380)-|a(CHEBI:"amyloid-beta")
100 a(CHEMBLA:CHEMBL38380)--bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: a(CHEMBLA:CHEMBL38380)--bp(GOBP:"non-canonical Wnt signaling pathway")
101 a(CHEMBLA:CHEMBL38380)--bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: a(CHEMBLA:CHEMBL38380)--bp(GOBP:"canonical Wnt signaling pathway")
102 a(CHEBI:"amyloid-beta")--bp(GOBP:"synapse pruning") "synapse pruning" is not in the GOBP namespace
104 UNSET Species = "Mus musculus" Missing citation; can't add: UNSET Species = "Mus musculus"
106 UNSET TextLocation = "Abstract" Missing citation; can't add: UNSET TextLocation = "Abstract"
108 SET TextLocation = "Result" Missing citation; can't add: SET TextLocation = "Result"
110 SET Support ="It has previously been reported that APP is a component of the Wnt-PCP molecular machinery. To confirm this, and to investigate any possible role of APP in Wnt signalling, we used reporter gene assays in HEK293A cells, with stimulation by Wnt3a (a type-1 pro canonical Wnt) or by Wnt5a (a type-2 pro non-canonical Wnt)." Missing citation; can't add: SET Support ="It has previously been reported that APP is a component of the Wnt-PCP molecular machinery. To confirm this, and to investigate any possible role of APP in Wnt signalling, we used reporter gene assays in HEK293A cells, with stimulation by Wnt3a (a type-1 pro canonical Wnt) or by Wnt5a (a type-2 pro non-canonical Wnt)."
114 SET CellLINE = "HEK293A" Missing citation; can't add: SET CellLINE = "HEK293A"
115 SET Assay = "Reporter Gene Assays" Missing citation; can't add: SET Assay = "Reporter Gene Assays"
117 p(HGNC:APP)-- bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:APP)-- bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
119 UNSET CellLINE = "HEK293A" Missing citation; can't add: UNSET CellLINE = "HEK293A"
120 UNSET Assay = "Reporter Gene Assays" Missing citation; can't add: UNSET Assay = "Reporter Gene Assays"
122 SET Support ="APP did though potentiate both Wnt3a-driven Wnt-β-catenin signalling and Wnt5a-driven Wnt-PCP signalling. These findings confirm the previously reported involvement of APP in Wnt-PCP signalling, and identify a new role of APP in Wnt-β-catenin signalling." Missing citation; can't add: SET Support ="APP did though potentiate both Wnt3a-driven Wnt-β-catenin signalling and Wnt5a-driven Wnt-PCP signalling. These findings confirm the previously reported involvement of APP in Wnt-PCP signalling, and identify a new role of APP in Wnt-β-catenin signalling."
125 composite(p(HGNC:APP), p(HGNC:WNT3A))->bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: composite(p(HGNC:APP), p(HGNC:WNT3A))->bp(GOBP:"canonical Wnt signaling pathway")
126 composite(p(HGNC:APP), p(HGNC:WNT5A))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: composite(p(HGNC:APP), p(HGNC:WNT5A))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
128 SET Support = "APP has previously been shown to interact with Vangl2 , a Wnt-PCP-specific co-receptor protein, and independently has been shown to bind LRP6, a receptor component of the Wnt-β-catenin pathway." Missing citation; can't add: SET Support = "APP has previously been shown to interact with Vangl2 , a Wnt-PCP-specific co-receptor protein, and independently has been shown to bind LRP6, a receptor component of the Wnt-β-catenin pathway."
131 complex(p(HGNC:APP),p(HGNC:VANGL2))--bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: complex(p(HGNC:APP),p(HGNC:VANGL2))--bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
132 composite(p(HGNC:APP),p(HGNC:LRP6))--bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: composite(p(HGNC:APP),p(HGNC:LRP6))--bp(GOBP:"canonical Wnt signaling pathway")
135 SET Support = "The ability of APP to potentiate Wnt-β-catenin signalling in response to Wnt3a was enhanced by the overexpression of LRP6, and attenuated by Vangl2. Conversely, the ability of APP to potentiate Wnt-PCP signalling in response to Wnt5a was enhanced by Vangl2 and attenuated by LRP6." Missing citation; can't add: SET Support = "The ability of APP to potentiate Wnt-β-catenin signalling in response to Wnt3a was enhanced by the overexpression of LRP6, and attenuated by Vangl2. Conversely, the ability of APP to potentiate Wnt-PCP signalling in response to Wnt5a was enhanced by Vangl2 and attenuated by LRP6."
138 composite(p(HGNC:APP), p(HGNC:WNT3A))->bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: composite(p(HGNC:APP), p(HGNC:WNT3A))->bp(GOBP:"canonical Wnt signaling pathway")
139 p(HGNC:LRP6) positiveCorrelation bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:LRP6) positiveCorrelation bp(GOBP:"canonical Wnt signaling pathway")
140 p(HGNC:VANGL2) negativeCorrelation bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:VANGL2) negativeCorrelation bp(GOBP:"canonical Wnt signaling pathway")
141 composite(p(HGNC:APP), p(HGNC:WNT5A))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: composite(p(HGNC:APP), p(HGNC:WNT5A))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
142 p(HGNC:VANGL2) positiveCorrelation bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:VANGL2) positiveCorrelation bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
143 p(HGNC:LRP6)negativeCorrelation bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:LRP6)negativeCorrelation bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
146 SET Support = "An involvement of APP in Wnt signalling, which regulates synapse formation and stability, raises the question of whether familial AD mutations in APP may impact the activity of APP in Wnt signalling." Missing citation; can't add: SET Support = "An involvement of APP in Wnt signalling, which regulates synapse formation and stability, raises the question of whether familial AD mutations in APP may impact the activity of APP in Wnt signalling."
149 p(HGNC:APP)--bp(GOBP:"Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP)--bp(GOBP:"Wnt signaling pathway")
150 bp(GOBP:"Wnt signaling pathway")--bp(GOBP:"synapse organization") Missing citation; can't add: bp(GOBP:"Wnt signaling pathway")--bp(GOBP:"synapse organization")
152 SET Support = "Using the reporter gene assays in HEK293A cells, we compared the effects of the wild-type form of APP695 with the Swedish mutant form (KM670/671NL) (APPSwe). In contrast with wild-type APP which, as before, potentiated both canonical and non-canonical Wnt signalling, the Swedish mutant form of APP antagonised canonical Wnt signalling,and potentiated non-canonical Wnt signalling to agreater degree than wild-type APP (APPWT)." Missing citation; can't add: SET Support = "Using the reporter gene assays in HEK293A cells, we compared the effects of the wild-type form of APP695 with the Swedish mutant form (KM670/671NL) (APPSwe). In contrast with wild-type APP which, as before, potentiated both canonical and non-canonical Wnt signalling, the Swedish mutant form of APP antagonised canonical Wnt signalling,and potentiated non-canonical Wnt signalling to agreater degree than wild-type APP (APPWT)."
157 SET Cell line = "HEK293A" Missing citation; can't add: SET Cell line = "HEK293A"
158 SET Assay = "Reporter Gene Assays" Missing citation; can't add: SET Assay = "Reporter Gene Assays"
160 p(HGNC:APP)->bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP)->bp(GOBP:"canonical Wnt signaling pathway")
161 p(HGNC:APP)->bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP)->bp(GOBP:"non-canonical Wnt signaling pathway")
162 p(HGNC:APP,var("p.Lys670Asn"))-|bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP,var("p.Lys670Asn"))-|bp(GOBP:"canonical Wnt signaling pathway")
163 p(HGNC:APP,var("p.Met671Leu"))-|bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP,var("p.Met671Leu"))-|bp(GOBP:"canonical Wnt signaling pathway")
164 p(HGNC:APP,var("p.Lys670Asn"))->bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP,var("p.Lys670Asn"))->bp(GOBP:"non-canonical Wnt signaling pathway")
165 p(HGNC:APP,var("p.Met671Leu"))->bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP,var("p.Met671Leu"))->bp(GOBP:"non-canonical Wnt signaling pathway")
167 UNSET Cell line = "HEK293A" Missing citation; can't add: UNSET Cell line = "HEK293A"
168 UNSET Assay = "Reporter Gene Assays" Missing citation; can't add: UNSET Assay = "Reporter Gene Assays"
170 SET Support = "The pattern of LRP6 and Vangl2-modification of the Wnt signalling activities of APPSwe was similar to that of APPWT, although APPSwe still inhibited canonical signalling when co-expressed with LRP6 and enhanced non-canonical further still in the presence of exogenous Vangl2." Missing citation; can't add: SET Support = "The pattern of LRP6 and Vangl2-modification of the Wnt signalling activities of APPSwe was similar to that of APPWT, although APPSwe still inhibited canonical signalling when co-expressed with LRP6 and enhanced non-canonical further still in the presence of exogenous Vangl2."
174 composite(p(HGNC:LRP6),p(HGNC:APP,var("p.Lys670Asn")))-|bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: composite(p(HGNC:LRP6),p(HGNC:APP,var("p.Lys670Asn")))-|bp(GOBP:"canonical Wnt signaling pathway")
175 composite(p(HGNC:LRP6),p(HGNC:APP,var("p.Met671Leu")))-|bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: composite(p(HGNC:LRP6),p(HGNC:APP,var("p.Met671Leu")))-|bp(GOBP:"canonical Wnt signaling pathway")
176 composite(p(HGNC:LRP6),p(HGNC:APP,var("p.Lys670Asn")))->bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: composite(p(HGNC:LRP6),p(HGNC:APP,var("p.Lys670Asn")))->bp(GOBP:"non-canonical Wnt signaling pathway")
177 composite(p(HGNC:LRP6),p(HGNC:APP,var("p.Met671Leu")))->bp(GOBP:"non-canonical Wnt signaling pathway") Missing citation; can't add: composite(p(HGNC:LRP6),p(HGNC:APP,var("p.Met671Leu")))->bp(GOBP:"non-canonical Wnt signaling pathway")
179 SET Support = "It is very well established that familial AD mutations of APP confer increased production of Aβ, and we have found that the Swedish variant shifts the balance of Wnt signalling activity away from Wnt-β-catenin towards Wnt-PCP." Missing citation; can't add: SET Support = "It is very well established that familial AD mutations of APP confer increased production of Aβ, and we have found that the Swedish variant shifts the balance of Wnt signalling activity away from Wnt-β-catenin towards Wnt-PCP."
182 p(HGNC:APP,var("p.Val717Leu"))->path (MESHD:"Alzheimer Disease") Missing citation; can't add: p(HGNC:APP,var("p.Val717Leu"))->path (MESHD:"Alzheimer Disease")
183 path(MESHD:"Alzheimer Disease")->a(CHEBI:"amyloid-beta") Missing citation; can't add: path(MESHD:"Alzheimer Disease")->a(CHEBI:"amyloid-beta")
184 p(HGNC:APP,var("p.Lys670Asn"))-|bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP,var("p.Lys670Asn"))-|bp(GOBP:"canonical Wnt signaling pathway")
185 p(HGNC:APP,var("p.Met671Leu"))-|bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP,var("p.Met671Leu"))-|bp(GOBP:"canonical Wnt signaling pathway")
186 p(HGNC:APP,var("p.Lys670Asn"))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:APP,var("p.Lys670Asn"))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
187 p(HGNC:APP,var("p.Met671Leu"))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:APP,var("p.Met671Leu"))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
190 SET Support = "As expected, cells expressing the Swedish mutant form of APP695 produced much more Aβ than the control wildtype-expressing cells. In cells expressing either wild-type or Swedish APP, the amount of Aβ produced was reduced in cells stimulated with Wnt3a, which promotes Wnt-βcatenin signalling, whereas Aβ production was enhanced in cells stimulated with Wnt5a, which promotes Wnt-PCP signalling." Missing citation; can't add: SET Support = "As expected, cells expressing the Swedish mutant form of APP695 produced much more Aβ than the control wildtype-expressing cells. In cells expressing either wild-type or Swedish APP, the amount of Aβ produced was reduced in cells stimulated with Wnt3a, which promotes Wnt-βcatenin signalling, whereas Aβ production was enhanced in cells stimulated with Wnt5a, which promotes Wnt-PCP signalling."
194 p(HGNC:WNT3A)-|p(HGNC:APP) Missing citation; can't add: p(HGNC:WNT3A)-|p(HGNC:APP)
195 p(HGNC:WNT3A)->bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:WNT3A)->bp(GOBP:"canonical Wnt signaling pathway")
196 p(HGNC:WNT5A)->p(HGNC:APP) Missing citation; can't add: p(HGNC:WNT5A)->p(HGNC:APP)
197 p(HGNC:WNT5A)->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:WNT5A)->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
200 SET Support = "Co-expression of LRP6 with APP reduced the production of Aβ, while co-expression of Vangl2 with APP led to increased Aβ production. In each case Aβ production was higher under conditions that favour Wnt-PCP signalling and decreased under conditions that favour Wnt-β-catenin signalling. Comparison of signalling activity and Aβ production under each of the different conditions showed clearly that Aβ production was negatively correlated with Wnt-β-catenin signalling activity and positively correlated with Wnt-PCP signalling." Missing citation; can't add: SET Support = "Co-expression of LRP6 with APP reduced the production of Aβ, while co-expression of Vangl2 with APP led to increased Aβ production. In each case Aβ production was higher under conditions that favour Wnt-PCP signalling and decreased under conditions that favour Wnt-β-catenin signalling. Comparison of signalling activity and Aβ production under each of the different conditions showed clearly that Aβ production was negatively correlated with Wnt-β-catenin signalling activity and positively correlated with Wnt-PCP signalling."
205 composite(r(HGNC:LRP6),r(HGNC:APP))-|a(CHEBI:"amyloid-beta") Missing citation; can't add: composite(r(HGNC:LRP6),r(HGNC:APP))-|a(CHEBI:"amyloid-beta")
206 composite(r(HGNC:VANGL2),r(HGNC:APP))->a(CHEBI:"amyloid-beta") Missing citation; can't add: composite(r(HGNC:VANGL2),r(HGNC:APP))->a(CHEBI:"amyloid-beta")
207 bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation a(CHEBI:"amyloid-beta") Missing citation; can't add: bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation a(CHEBI:"amyloid-beta")
208 bp(GOBP:"canonical Wnt signaling pathway") negativeCorrelation a(CHEBI:"amyloid-beta") Missing citation; can't add: bp(GOBP:"canonical Wnt signaling pathway") negativeCorrelation a(CHEBI:"amyloid-beta")
211 SET Support = "As the Wnt signalling modulator Dkk1 has been shown to be central in Aβ synaptotoxicity, we assessed the effects of APP on Dkk1-mediated modulation of canonical and non-canonical signalling activity. Overexpression of APP enhanced the inhibitory effects of Dkk1 on Wnt3a induced Wnt-β-catenin signalling, counteracting the enhanced activity resulting from APP overexpression and reducing the IC50 of Dkk1 to 122 ng/mL from 173 ng/mLin the absence of APP." Missing citation; can't add: SET Support = "As the Wnt signalling modulator Dkk1 has been shown to be central in Aβ synaptotoxicity, we assessed the effects of APP on Dkk1-mediated modulation of canonical and non-canonical signalling activity. Overexpression of APP enhanced the inhibitory effects of Dkk1 on Wnt3a induced Wnt-β-catenin signalling, counteracting the enhanced activity resulting from APP overexpression and reducing the IC50 of Dkk1 to 122 ng/mL from 173 ng/mLin the absence of APP."
216 p(HGNC:DKK1)--bp(GOBP:"Wnt signaling pathway") Missing citation; can't add: p(HGNC:DKK1)--bp(GOBP:"Wnt signaling pathway")
217 p(HGNC:DKK1) positiveCorrelation bp("Aβ synaptotoxicity") [pos:36] "Aβ synaptotoxicity" should be qualified with a valid namespace
218 r(HGNC:APP) negativeCorrelation act(p(HGNC:DKK1)) Missing citation; can't add: r(HGNC:APP) negativeCorrelation act(p(HGNC:DKK1))
219 composite(p(HGNC:DKK1),p(HGNC:WNT3A))-|bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: composite(p(HGNC:DKK1),p(HGNC:WNT3A))-|bp(GOBP:"canonical Wnt signaling pathway")
221 SET Support = "In contrast, the stimulatory effects of Dkk1 on WntPCP signalling induced by Wnt5a were enhanced by APP overexpression, decreasing the EC50 of Dkk1 to 599 ng/ mL from 1405 ng/mL. These data suggest that APP can enhance the potency of Dkk1 to modulate Wnt signalling." Missing citation; can't add: SET Support = "In contrast, the stimulatory effects of Dkk1 on WntPCP signalling induced by Wnt5a were enhanced by APP overexpression, decreasing the EC50 of Dkk1 to 599 ng/ mL from 1405 ng/mL. These data suggest that APP can enhance the potency of Dkk1 to modulate Wnt signalling."
224 r(HGNC:APP) positiveCorrelation act(p(HGNC:DKK1)) Missing citation; can't add: r(HGNC:APP) positiveCorrelation act(p(HGNC:DKK1))
225 composite(p(HGNC:DKK1),p(HGNC:WNT5A)) ->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: composite(p(HGNC:DKK1),p(HGNC:WNT5A)) ->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
226 composite (p(HGNC:APP),p(HGNC:DKK1))--bp(GOBP:"Wnt signaling pathway") Missing citation; can't add: composite (p(HGNC:APP),p(HGNC:DKK1))--bp(GOBP:"Wnt signaling pathway")
228 SET Support = "Aβ synaptoxicity is Dkk1-dependent and also appears to be APP-dependent.The results described above show that APP enhances the effects of Dkk1,changing the balance of Wnt signalling away from the Wnt-β-catenin pathway and towards Wnt-PCP signalling. Given the known differential effects on synapses of Wntβ-catenin and Wnt-PCP signalling, this suggests that APP might mediate the synaptotoxicity of Dkk1." Missing citation; can't add: SET Support = "Aβ synaptoxicity is Dkk1-dependent and also appears to be APP-dependent.The results described above show that APP enhances the effects of Dkk1,changing the balance of Wnt signalling away from the Wnt-β-catenin pathway and towards Wnt-PCP signalling. Given the known differential effects on synapses of Wntβ-catenin and Wnt-PCP signalling, this suggests that APP might mediate the synaptotoxicity of Dkk1."
232 p(HGNC:DKK1) -- bp("Aβ synaptotoxicity") [pos:19] "Aβ synaptotoxicity" should be qualified with a valid namespace
233 p(HGNC:APP)-- bp("Aβ synaptotoxicity") [pos:17] "Aβ synaptotoxicity" should be qualified with a valid namespace
234 p(HGNC:APP) -> p(MGI:Dkk1) Missing citation; can't add: p(HGNC:APP) -> p(MGI:Dkk1)
235 p(HGNC:APP) negativeCorrelation bp(GOBP:"canonical Wnt signaling pathway") Missing citation; can't add: p(HGNC:APP) negativeCorrelation bp(GOBP:"canonical Wnt signaling pathway")
236 p(HGNC:APP) positiveCorrelation bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:APP) positiveCorrelation bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
239 SET Support = "The Wnt-PCP signalling pathway acts through RhoA and ROCK, and can be inhibited pharmacologically, for example, with fasudil, a ROCK inhibitor that is in clinical use for the treatment of cerebral vasospasm. In reporter assays performed in HEK293A cells 10 µM fasudil completely reversed the stimulatory effect of Dkk1 and of Vangl2 on Wnt-PCP signalling. Fasudil also reversed the stimulatory effect of Vangl2 and Dkk1 on Aβ production in the same cells as determined by ELISA based quantification of Aβ1–40 levels in the paired culture media from the same experiments." Missing citation; can't add: SET Support = "The Wnt-PCP signalling pathway acts through RhoA and ROCK, and can be inhibited pharmacologically, for example, with fasudil, a ROCK inhibitor that is in clinical use for the treatment of cerebral vasospasm. In reporter assays performed in HEK293A cells 10 µM fasudil completely reversed the stimulatory effect of Dkk1 and of Vangl2 on Wnt-PCP signalling. Fasudil also reversed the stimulatory effect of Vangl2 and Dkk1 on Aβ production in the same cells as determined by ELISA based quantification of Aβ1–40 levels in the paired culture media from the same experiments."
244 SET Cell line = "HEK293A" Missing citation; can't add: SET Cell line = "HEK293A"
245 SET Dosage = "10 µM" Missing citation; can't add: SET Dosage = "10 µM"
246 SET Assay = "ELISA" Missing citation; can't add: SET Assay = "ELISA"
248 p(HGNC:RHOA)-- bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:RHOA)-- bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
249 p(HGNC:ROCK1)--bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: p(HGNC:ROCK1)--bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
250 a(CHEMBLA:CHEMBL38380)-|p(HGNC:ROCK1) Missing citation; can't add: a(CHEMBLA:CHEMBL38380)-|p(HGNC:ROCK1)
251 a(CHEMBLA:CHEMBL38380)-|bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") Missing citation; can't add: a(CHEMBLA:CHEMBL38380)-|bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway")
252 a(CHEMBLA:CHEMBL38380) negativeCorrelation path(MESHD:"Vasospasm, Intracranial") Missing citation; can't add: a(CHEMBLA:CHEMBL38380) negativeCorrelation path(MESHD:"Vasospasm, Intracranial")
253 a(CHEMBLA:CHEMBL38380) negativeCorrelation p(HGNC:DKK1) Missing citation; can't add: a(CHEMBLA:CHEMBL38380) negativeCorrelation p(HGNC:DKK1)
254 a(CHEMBLA:CHEMBL38380) negativeCorrelation p(HGNC:VANGL2) Missing citation; can't add: a(CHEMBLA:CHEMBL38380) negativeCorrelation p(HGNC:VANGL2)
256 UNSET Cell line = "HEK293A" Missing citation; can't add: UNSET Cell line = "HEK293A"
257 UNSET Dosage = "10 µM" Missing citation; can't add: UNSET Dosage = "10 µM"
258 UNSET Assay = "ELISA" Missing citation; can't add: UNSET Assay = "ELISA"
260 SET Support = "To investigate the relevance of the findings described above in a neuronal context, we examined the effects of fasudil on Dkk1-driven dendritic spine withdrawal and Aβ production in primary cultures of rat cortical neurons. Consistent with our previous findings, treatment with Dkk1 resulted in substantial loss of dendritic spines, which was blocked by 10 µM fasudil treatment. The amounts of endogenous Aβ species (Aβ1–38, Aβ1–40 and Aβ1–42) secreted into the culture media by these treated neurons were determined using a multiplex assay.In addition to causing a significant reduction in the numbers of dendritic spines, Dkk1 treatment also resulted a substantial increase in levels of all three Aβ species.In the absence of exogenous Dkk1, fasudil had little effect on the amounts of Aβ secreted by the neurons. Notably, in parallel with the protective effect of fasudil on synapses treatment with fasudil reversed the stimulatory effects of Dkk1 on Aβ production." Missing citation; can't add: SET Support = "To investigate the relevance of the findings described above in a neuronal context, we examined the effects of fasudil on Dkk1-driven dendritic spine withdrawal and Aβ production in primary cultures of rat cortical neurons. Consistent with our previous findings, treatment with Dkk1 resulted in substantial loss of dendritic spines, which was blocked by 10 µM fasudil treatment. The amounts of endogenous Aβ species (Aβ1–38, Aβ1–40 and Aβ1–42) secreted into the culture media by these treated neurons were determined using a multiplex assay.In addition to causing a significant reduction in the numbers of dendritic spines, Dkk1 treatment also resulted a substantial increase in levels of all three Aβ species.In the absence of exogenous Dkk1, fasudil had little effect on the amounts of Aβ secreted by the neurons. Notably, in parallel with the protective effect of fasudil on synapses treatment with fasudil reversed the stimulatory effects of Dkk1 on Aβ production."
268 SET Species = "Rattus norvegicus" Missing citation; can't add: SET Species = "Rattus norvegicus"
269 SET MeshAnatomy = "Neurons" Missing citation; can't add: SET MeshAnatomy = "Neurons"
270 SET Assay = "Multiplex Assay" Missing citation; can't add: SET Assay = "Multiplex Assay"
272 p(RGD:Dkk1)-| a(GOCC:"dendritic spine") Missing citation; can't add: p(RGD:Dkk1)-| a(GOCC:"dendritic spine")
273 p(RGD:Dkk1)->a(CHEBI:"amyloid-beta") Missing citation; can't add: p(RGD:Dkk1)->a(CHEBI:"amyloid-beta")
275 UNSET Species = "Rattus norvegicus" Missing citation; can't add: UNSET Species = "Rattus norvegicus"
276 UNSET MeshAnatomy = "Neurons" Missing citation; can't add: UNSET MeshAnatomy = "Neurons"
277 UNSET Assay = "Multiplex Assay" Missing citation; can't add: UNSET Assay = "Multiplex Assay"
279 SET Support = "In the absence of exogenous Dkk1, fasudil had little effect on the amounts of Aβ secreted by the neurons. Notably, in parallel with the protective effect of fasudil on synapses treatment with fasudil reversed the stimulatory effects of Dkk1 on Aβ production." Missing citation; can't add: SET Support = "In the absence of exogenous Dkk1, fasudil had little effect on the amounts of Aβ secreted by the neurons. Notably, in parallel with the protective effect of fasudil on synapses treatment with fasudil reversed the stimulatory effects of Dkk1 on Aβ production."
282 SET Species = "Rattus norvegicus" Missing citation; can't add: SET Species = "Rattus norvegicus"
283 SET MeshAnatomy = "Synapses" Missing citation; can't add: SET MeshAnatomy = "Synapses"
285 p(RGD:Dkk1)->a(CHEBI:"amyloid-beta") Missing citation; can't add: p(RGD:Dkk1)->a(CHEBI:"amyloid-beta")
286 a(CHEMBLA:CHEMBL38380) negativeCorrelation p(RGD:Dkk1) Missing citation; can't add: a(CHEMBLA:CHEMBL38380) negativeCorrelation p(RGD:Dkk1)
288 UNSET Species = "Rattus norvegicus" Missing citation; can't add: UNSET Species = "Rattus norvegicus"
289 UNSET MeshAnatomy = "Synapses" Missing citation; can't add: UNSET MeshAnatomy = "Synapses"
291 SET Support = "We previously demonstrated that fasudil protects against both Aβ- and Dkk1-driven synapse loss and cognitive impairment, and show above that fasudil can inhibit the production of Aβ by neurons stimulated with Dkk1. We therefore investigated whether fasudil might also attenuate amyloid pathology in vivo. These experiments used the 3xTG-AD transgenic mouse model27, which express human APPSwe, as well as mutant human tau (MAPT-P301L) and mutant presenilin-1 (PSEN1- M146V). In this model27, Aβ pathology is readily detectable at 12 months of age, and abundant in 18-month old mice, which show substantial soluble and insoluble amyloid load in brain, including plaque-like, Aβ-immunoreactive deposits." Missing citation; can't add: SET Support = "We previously demonstrated that fasudil protects against both Aβ- and Dkk1-driven synapse loss and cognitive impairment, and show above that fasudil can inhibit the production of Aβ by neurons stimulated with Dkk1. We therefore investigated whether fasudil might also attenuate amyloid pathology in vivo. These experiments used the 3xTG-AD transgenic mouse model27, which express human APPSwe, as well as mutant human tau (MAPT-P301L) and mutant presenilin-1 (PSEN1- M146V). In this model27, Aβ pathology is readily detectable at 12 months of age, and abundant in 18-month old mice, which show substantial soluble and insoluble amyloid load in brain, including plaque-like, Aβ-immunoreactive deposits."
297 a(CHEBI:"amyloid-beta") positiveCorrelation bp(GOBP:"synapse pruning") "synapse pruning" is not in the GOBP namespace
298 p(HGNC:DKK1) positiveCorrelation bp(GOBP:"synapse pruning") "synapse pruning" is not in the GOBP namespace
299 a(CHEBI:"amyloid-beta") positiveCorrelation path(MESHD:"Cognitive Dysfunction") Missing citation; can't add: a(CHEBI:"amyloid-beta") positiveCorrelation path(MESHD:"Cognitive Dysfunction")
300 p(HGNC:DKK1) positiveCorrelation path(MESHD:"Cognitive Dysfunction") Missing citation; can't add: p(HGNC:DKK1) positiveCorrelation path(MESHD:"Cognitive Dysfunction")
301 a(CHEMBLA:CHEMBL38380) negativeCorrelation bp(GOBP:"synapse pruning") "synapse pruning" is not in the GOBP namespace
302 a(CHEMBLA:CHEMBL38380) negativeCorrelation path(MESHD:"Cognitive Dysfunction") Missing citation; can't add: a(CHEMBLA:CHEMBL38380) negativeCorrelation path(MESHD:"Cognitive Dysfunction")
303 a(CHEMBLA:CHEMBL38380) negativeCorrelation act(a(CHEBI:"amyloid-beta")) Missing citation; can't add: a(CHEMBLA:CHEMBL38380) negativeCorrelation act(a(CHEBI:"amyloid-beta"))
304 a(CHEMBLA:CHEMBL38380) negativeCorrelation act(p(HGNC:DKK1)) Missing citation; can't add: a(CHEMBLA:CHEMBL38380) negativeCorrelation act(p(HGNC:DKK1))
306 SET MeshAnatomy = "Neurons" Missing citation; can't add: SET MeshAnatomy = "Neurons"
308 composite (a(CHEMBLA:CHEMBL38380),p(MGI:Dkk1)) -| a(CHEBI:"amyloid-beta") Missing citation; can't add: composite (a(CHEMBLA:CHEMBL38380),p(MGI:Dkk1)) -| a(CHEBI:"amyloid-beta")
310 SET Species = "Mus musculus" Missing citation; can't add: SET Species = "Mus musculus"
311 SET MouseStrain = "3xTG-AD" Missing citation; can't add: SET MouseStrain = "3xTG-AD"
313 path(MESHD:"Plaque, Amyloid") -- path (MESHD:"Alzheimer Disease") Missing citation; can't add: path(MESHD:"Plaque, Amyloid") -- path (MESHD:"Alzheimer Disease")
314 bp("Aβ-immunoreactive deposits") -- path (MESHD:"Alzheimer Disease") [pos:3] "Aβ-immunoreactive deposits" should be qualified with a valid namespace
316 UNSET MeshAnatomy = "Neurons" Missing citation; can't add: UNSET MeshAnatomy = "Neurons"
317 UNSET Species = "Mus musculus" Missing citation; can't add: UNSET Species = "Mus musculus"
318 UNSET MouseStrain = "3xTG-AD" Missing citation; can't add: UNSET MouseStrain = "3xTG-AD"
320 SET Support = "The rostral poles of snap frozen hemi-brains were homogenised and the levels of soluble Aβ1–40 measured by ELISA. Animals receiving fasudil had significantly lower soluble Aβ1–40 levels than controls." Missing citation; can't add: SET Support = "The rostral poles of snap frozen hemi-brains were homogenised and the levels of soluble Aβ1–40 measured by ELISA. Animals receiving fasudil had significantly lower soluble Aβ1–40 levels than controls."
323 SET Assay = "ELISA" Missing citation; can't add: SET Assay = "ELISA"
325 a(CHEMBLA:CHEMBL38380) negativeCorrelation a(CHEBI:"amyloid-beta") Missing citation; can't add: a(CHEMBLA:CHEMBL38380) negativeCorrelation a(CHEBI:"amyloid-beta")
327 UNSET Assay = "ELISA" Missing citation; can't add: UNSET Assay = "ELISA"
329 SET Support = "Fixed hemi-brains were sectioned and immunostained using the anti-APP/Aβ antibody, 6E10. IHC shows that administration of fasudil for just 14 days substantially reduced amyloid plaque burden, across all cortical brain regions examined, and in hippocampal regions CA1 and subiculum." Missing citation; can't add: SET Support = "Fixed hemi-brains were sectioned and immunostained using the anti-APP/Aβ antibody, 6E10. IHC shows that administration of fasudil for just 14 days substantially reduced amyloid plaque burden, across all cortical brain regions examined, and in hippocampal regions CA1 and subiculum."
332 SET Anatomy = "subiculum" Missing citation; can't add: SET Anatomy = "subiculum"
333 SET MeshAnatomy = "CA1,hippocampal" Missing citation; can't add: SET MeshAnatomy = "CA1,hippocampal"
334 SET Assay = "IHC" Missing citation; can't add: SET Assay = "IHC"
336 a(CHEMBLA:CHEMBL38380)-| a(CHEBI:"amyloid-beta") Missing citation; can't add: a(CHEMBLA:CHEMBL38380)-| a(CHEBI:"amyloid-beta")
338 UNSET Anatomy = "subiculum" Missing citation; can't add: UNSET Anatomy = "subiculum"
339 UNSET MeshAnatomy = "CA1,hippocampal" Missing citation; can't add: UNSET MeshAnatomy = "CA1,hippocampal"
340 UNSET Assay = "IHC" Missing citation; can't add: UNSET Assay = "IHC"

Top Warnings

Error Frequency
"synapse pruning" is not in the GOBP namespace 9
Missing citation; can't add: composite(p(HGNC:APP), p(HGNC:WNT5A))->bp(GOBP:"Wnt signaling pathway, planar cell polarity pathway") 2
Missing citation; can't add: p(HGNC:APP,var("p.Lys670Asn"))-|bp(GOBP:"canonical Wnt signaling pathway") 2
Missing citation; can't add: composite(p(HGNC:APP), p(HGNC:WNT3A))->bp(GOBP:"canonical Wnt signaling pathway") 2
Missing citation; can't add: UNSET Cell line = "HEK293A" 2
"VANGl2" is not in the HGNC namespace 2
Missing citation; can't add: UNSET Assay = "Reporter Gene Assays" 2
Missing citation; can't add: UNSET Assay = "ELISA" 2
Missing citation; can't add: SET Assay = "Reporter Gene Assays" 2
Missing citation; can't add: SET Species = "Mus musculus" 2
Missing citation; can't add: p(HGNC:APP,var("p.Met671Leu"))-|bp(GOBP:"canonical Wnt signaling pathway") 2
Missing citation; can't add: UNSET MeshAnatomy = "Neurons" 2
Missing citation; can't add: a(CHEBI:"amyloid-beta")->bp(GOBP:"non-canonical Wnt signaling pathway") 2
Missing citation; can't add: SET MeshAnatomy = "Neurons" 2
Missing citation; can't add: UNSET Species = "Mus musculus" 2
Missing citation; can't add: UNSET Species = "Rattus norvegicus" 2
Missing citation; can't add: SET Assay = "ELISA" 2
Missing citation; can't add: p(RGD:Dkk1)->a(CHEBI:"amyloid-beta") 2
Missing citation; can't add: SET Cell line = "HEK293A" 2
Missing citation; can't add: SET Species = "Rattus norvegicus" 2

Naked Names 3

Names referenced without a namespace are antithetical to reproducible science and data integration practices. The list of "naked names" can be downloaded here for further use with tools to help find the appropriate names.

Namespaces with Incorrect Names 2

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.