Provenance

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charles.hoyt@scai.fraunhofer.de at 2018-04-03 15:19:26
Authors
Causal Biological Networks Database
Contact
CausalBiologicalNetworks.RD@pmi.com
Description
The Wnt Signaling network depicts the causal mechanisms that regulate aspects of Wnt signaling primarily in the context of heightened cell proliferation observed following lung injury. The network includes multiple pathways leading to the degradation of beta-catenin as it relates to Wnt signaling.
License
Please cite: - www.causalbionet.com - https://bionet.sbvimprover.com as well as any relevant publications. The sbv IMPROVER project, the website and the Symposia are part of a collaborative project designed to enable scientists to learn about and contribute to the development of a new crowd sourcing method for verification of scientific data and results. The current challenges, website and biological network models were developed and are maintained as part of a collaboration among Selventa, OrangeBus and ADS. The project is led and funded by Philip Morris International. For more information on the focus of Philip Morris International’s research, please visit www.pmi.com.
Number Nodes
80
Number Edges
177
Number Components
9
Network Density
0.0280063
Average Degree
2.2125
Number Citations
85
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 51%
Wnt-2.0-Hs v2.0 41%
Wnt-2.0-Mm v2.0 40%
Selventa Protein Families Definitions v20150611 29%
Fibrosis-2.0-Rn v2.0 24%
Growth Factor-2.0-Rn v2.0 19%
Notch-2.0-Rn v2.0 17%
Mapk-2.0-Rn v2.0 16%
BEL Framework Small Corpus Document v20150611 15%
Immune Regulation of Tissue Repair-2.0-Rn v2.0 15%

Sample Edges

Sample Nodes

p(RGD:Fos)

In-Edges: 23 | Out-Edges: 6 | Explore Neighborhood | Download JSON

p(HGNC:CXCL8)

In-Edges: 334 | Out-Edges: 142 | Explore Neighborhood | Download JSON

a(CHEBI:nicotine)

In-Edges: 45 | Out-Edges: 398 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.