Upload at 2018-04-03 15:19:20
Causal Biological Networks Database
The Treg Signaling network depicts the causal mechanisms that are activated in CD4+ Foxp3+ regulatory T-cells following T-cell receptor (TCR) ligation. Expanding on these processes, the network highlights the chemokines secreted by macrophages and dendritic cells, as well as the cognate T-cell receptors, involved in mediating T-cell recruitment to compromised lung tissue during COPD development.
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Th17 Signaling-2.0-Rn v2.0 42%
BEL Framework Large Corpus Document v20170611 40%
Th1-Th2 Signaling-2.0-Rn v2.0 40%
Selventa Protein Families Definitions v20150611 34%
Dendritic Cell Signaling-2.0-Rn v2.0 34%
Cytotoxic T-cell Signaling-2.0-Rn v2.0 32%
Immune Regulation of Tissue Repair-2.0-Rn v2.0 18%
NK Signaling-2.0-Rn v2.0 15%
Treg Signaling-2.0-Hs v2.0 14%
Treg Signaling-2.0-Mm v2.0 14%

Sample Edges

act(p(RGD:Cxcr3), ma(cat)) increases bp(GOBP:"lymphocyte chemotaxis")

neutralization of CXCR3 reduced MIG/CXCL9-induced T lymphocyte proliferation and the number of IFN-gamma-positive spots PubMed:15187119

act(p(RGD:Cxcr3), ma(cat)) increases bp(GOBP:"lymphocyte chemotaxis")

supernatants harvested from stimulated PMN induced migration and rapid integrin-dependent adhesion of CXCR3-expressing lymphocytes; these activities were significantly reduced by neutralizing anti-MIG and anti-IP-10 Abs, PubMed:10202039

p(RGD:Ccl3) directlyIncreases act(p(RGD:Ccr5), ma(cat))

Numerous studies have shown that immature human and mouse blood- and bone marrow-derived DC subsets express a panel of inflammatory chemokine receptors (CCR1-6,8,9, CXCR3,4, CX3CR1) [Table 1 and reviewed in (1-5)]. [Table 1 Chemokine receptors expressed by DC and the functional outcome of receptor ligation}] PubMed:19028258

p(RGD:Cxcl9) directlyIncreases act(p(RGD:Cxcr3), ma(cat))

By using a CXCR3 ligand reporter mouse, we found that stromal cells predominately expressed the chemokine ligand CXCL9 whereas hematopoietic cells expressed CXCL10 in lymph nodes (LNs). Dendritic cell (DC)-derived CXCL10 facilitated T cell-DC interactions in LNs during T cell priming while both chemokines guided intranodal positioning of CD4(+) T cells to interfollicular and medullary zones. Thus, different chemokines acting on the same receptor can function locally to facilitate DC-T cell interactions and globally to influence intranodal positioning, and both functions contribute to Th1 cell differentiation. PubMed:23123063

Sample Nodes


In-Edges: 11 | Out-Edges: 19 | Explore Neighborhood | Download JSON


In-Edges: 45 | Out-Edges: 79 | Explore Neighborhood | Download JSON


In-Edges: 166 | Out-Edges: 99 | Explore Neighborhood | Download JSON


In-Edges: 7 | Out-Edges: 13 | Explore Neighborhood | Download JSON


In-Edges: 26 | Out-Edges: 10 | Explore Neighborhood | Download JSON


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