The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|Th17 Signaling-2.0-Rn v2.0||42%|
|BEL Framework Large Corpus Document v20170611||40%|
|Th1-Th2 Signaling-2.0-Rn v2.0||40%|
|Selventa Protein Families Definitions v20150611||34%|
|Dendritic Cell Signaling-2.0-Rn v2.0||34%|
|Cytotoxic T-cell Signaling-2.0-Rn v2.0||32%|
|Immune Regulation of Tissue Repair-2.0-Rn v2.0||18%|
|NK Signaling-2.0-Rn v2.0||15%|
|Treg Signaling-2.0-Hs v2.0||14%|
|Treg Signaling-2.0-Mm v2.0||14%|
neutralization of CXCR3 reduced MIG/CXCL9-induced T lymphocyte proliferation and the number of IFN-gamma-positive spots
supernatants harvested from stimulated PMN induced migration and rapid integrin-dependent adhesion of CXCR3-expressing lymphocytes; these activities were significantly reduced by neutralizing anti-MIG and anti-IP-10 Abs,
Numerous studies have shown that immature human and mouse blood- and bone marrow-derived DC subsets express a panel of inflammatory chemokine receptors (CCR1-6,8,9, CXCR3,4, CX3CR1) [Table 1 and reviewed in (1-5)]. [Table 1 Chemokine receptors expressed by DC and the functional outcome of receptor ligation}]
CXCR6, the receptor for CXCL16
By using a CXCR3 ligand reporter mouse, we found that stromal cells predominately expressed the chemokine ligand CXCL9 whereas hematopoietic cells expressed CXCL10 in lymph nodes (LNs). Dendritic cell (DC)-derived CXCL10 facilitated T cell-DC interactions in LNs during T cell priming while both chemokines guided intranodal positioning of CD4(+) T cells to interfollicular and medullary zones. Thus, different chemokines acting on the same receptor can function locally to facilitate DC-T cell interactions and globally to influence intranodal positioning, and both functions contribute to Th1 cell differentiation.
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