The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|Th17 Signaling-2.0-Rn v2.0||51%|
|Treg Signaling-2.0-Rn v2.0||40%|
|Cytotoxic T-cell Signaling-2.0-Rn v2.0||36%|
|BEL Framework Large Corpus Document v20170611||32%|
|NK Signaling-2.0-Rn v2.0||29%|
|Dendritic Cell Signaling-2.0-Rn v2.0||27%|
|Th1-Th2 Signaling-2.0-Hs v2.0||23%|
|Th1-Th2 Signaling-2.0-Mm v2.0||23%|
|Mast cell activation-2.0-Rn v2.0||20%|
accessed 2015-07-30, relationship = part_of
In vitro, gamma-secretase inhibitors extinguished expression of Notch, interferon-gamma and Tbx21 in TH1-polarized CD4+ cells, whereas ectopic expression of activated Notch1 restored Tbx21 transcription.
The four T cell receptor genes (Tcra, Tcrb, Tcrg, Tcrd) are assembled by V(D)J recombination according to distinct programs during intrathymic T cell development. These programs depend on genetic factors, including gene segment order and recombination signal sequences. They also depend on epigenetic factors. Regulated changes in chromatin structure, directed by enhancers and promoter, can modify the availability of recombination signal sequences to the RAG recombinase. Regulated changes in locus conformation may control the synapsis of distant recombination signal sequences, and regulated changes in subnuclear positioning may influence locus recombination events by unknown mechanisms. Together these influences may explain the ordered activation and inactivation of T cell receptor locus recombination events and the phenomenon of Tcrb allelic exclusion.
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