Upload at 2018-04-03 15:18:45
Causal Biological Networks Database
The Response to DNA Damage network depicts the causal mechanisms that are involved in multiple DNA damage response pathways. This includes those components that regulate TP53, TP63, and TP73 activities, the impact of G1/S and G2/M transitions of the cell cycle downstream of DNA damage, and DNA repair processes following single-strand and double-strand DNA damage. The network describes inhibition of DNA repair by various exogenous compounds, as well as components that function in nucleotide excision repair such as the XP proteins.\u003c/p\u003e\n\u003ch2\u003eJamboree Review Focus\u003c/h2\u003e\n\u003cp\u003eInterplay of components medaiting the processes of non-homologous end-joining (NHEJ) and homologous recombination (HR). Reviewed during Jamboree2014
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Response to DNA Damage-2.0-Hs v2.0 50%
Response to DNA Damage-2.0-Mm v2.0 46%
BEL Framework Large Corpus Document v20170611 40%
Clock-2.0-Rn v2.0 27%
Cell Cycle-2.0-Rn v2.0 22%
Nuclear Receptors-2.0-Rn v2.0 16%
Senescence-2.0-Rn v2.0 15%
BEL Framework Example 3 Document v2015611 14%
Clock-2.0-Hs v2.0 14%
Epigenetics-2.0-Rn v2.0 12%

Sample Edges

Sample Nodes

p(SFAM:"MAPK p38 Family")

In-Edges: 300 | Out-Edges: 234 | Explore Neighborhood | Download JSON

a(CHEBI:"nitric oxide")

In-Edges: 455 | Out-Edges: 538 | Classes: 3 | Explore Neighborhood | Download JSON


In-Edges: 38 | Out-Edges: 22 | Explore Neighborhood | Download JSON


In-Edges: 29 | Out-Edges: 49 | Explore Neighborhood | Download JSON


BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.