Provenance

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charles.hoyt@scai.fraunhofer.de at 2018-04-03 15:18:45
Authors
Causal Biological Networks Database
Contact
CausalBiologicalNetworks.RD@pmi.com
Description
The Response to DNA Damage network depicts the causal mechanisms that are involved in multiple DNA damage response pathways. This includes those components that regulate TP53, TP63, and TP73 activities, the impact of G1/S and G2/M transitions of the cell cycle downstream of DNA damage, and DNA repair processes following single-strand and double-strand DNA damage. The network describes inhibition of DNA repair by various exogenous compounds, as well as components that function in nucleotide excision repair such as the XP proteins.\u003c/p\u003e\n\u003ch2\u003eJamboree Review Focus\u003c/h2\u003e\n\u003cp\u003eInterplay of components medaiting the processes of non-homologous end-joining (NHEJ) and homologous recombination (HR). Reviewed during Jamboree2014
License
Please cite: - www.causalbionet.com - https://bionet.sbvimprover.com as well as any relevant publications. The sbv IMPROVER project, the website and the Symposia are part of a collaborative project designed to enable scientists to learn about and contribute to the development of a new crowd sourcing method for verification of scientific data and results. The current challenges, website and biological network models were developed and are maintained as part of a collaboration among Selventa, OrangeBus and ADS. The project is led and funded by Philip Morris International. For more information on the focus of Philip Morris International’s research, please visit www.pmi.com.
Number Nodes
224
Number Edges
522
Number Components
22
Network Density
0.01045
Average Degree
2.33036
Number Citations
256
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Response to DNA Damage-2.0-Hs v2.0 50%
Response to DNA Damage-2.0-Mm v2.0 46%
BEL Framework Large Corpus Document v20170611 40%
Clock-2.0-Rn v2.0 27%
Cell Cycle-2.0-Rn v2.0 22%
Nuclear Receptors-2.0-Rn v2.0 16%
Senescence-2.0-Rn v2.0 15%
BEL Framework Example 3 Document v2015611 14%
Clock-2.0-Hs v2.0 14%
Epigenetics-2.0-Rn v2.0 12%

Sample Edges

Sample Nodes

p(SFAM:"MAPK p38 Family")

In-Edges: 300 | Out-Edges: 234 | Explore Neighborhood | Download JSON

a(CHEBI:"nitric oxide")

In-Edges: 455 | Out-Edges: 538 | Classes: 3 | Explore Neighborhood | Download JSON

p(RGD:Rps6kb1)

In-Edges: 38 | Out-Edges: 22 | Explore Neighborhood | Download JSON

p(HGNC:BRCA1)

In-Edges: 29 | Out-Edges: 49 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.