Upload at 2018-04-03 15:18:35
Causal Biological Networks Database
The PGE2 network depicts the pathways exerting regulatory control of PGE2 in the context of cellular proliferation. The network includes cAMP-mediated activation of PKA-, Epac/Rap1- and Tiam1/Vav2-dependent pathways of Rac1 activation.
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 71%
Selventa Protein Families Definitions v20150611 57%
PGE2-2.0-Hs v2.0 44%
PGE2-2.0-Mm v2.0 43%
Growth Factor-2.0-Rn v2.0 29%
BEL Framework Small Corpus Document v20150611 27%
Wound Healing-2.0-Rn v2.0 25%
Hedgehog-2.0-Rn v2.0 24%
Angiogenesis-2.0-Rn v2.0 24%
Hedgehog-2.0-Hs v2.0 22%

Sample Edges

a(SCHEM:Dinoprostone) increases a(SCHEM:"cyclic AMP")

both Isoproterenol and PGE2 elevate and sustain increases in cyclic adenosine 3',5'-monophosphate (cAMP) PubMed:9809467

a(SCHEM:Dinoprostone) increases a(SCHEM:"cyclic AMP")

Both PGs caused cAMP-mediated activation of PKA-, Epac/Rap1- and Tiam1/Vav2-dependent pathways of Rac1 activation PubMed:17493609

a(SCHEM:Dinoprostone) increases a(SCHEM:"cyclic AMP")

3. On human washed platelet suspensions the PGE analogues, with the exception of butaprost,inhibited the rise in adenosine 3':5'-cyclic monophosphate (cyclic AMP) induced by cicaprost (8 nM).PGE2 produced a monophasic inhibition curve (IC50 = 5.4 nM, 92% inhibition at 600 nM). PubMed:8448586

a(SCHEM:Dinoprostone) increases a(SCHEM:"cyclic AMP")

An increase of intracellular cAMP mediated by prostaglandin E2 (PGE2) has been shown to delay spontaneous apoptosis of neutrophils. PubMed:10947062

Sample Nodes


In-Edges: 8 | Out-Edges: 14 | Explore Neighborhood | Download JSON


In-Edges: 54 | Out-Edges: 15 | Explore Neighborhood | Download JSON


In-Edges: 334 | Out-Edges: 142 | Explore Neighborhood | Download JSON


In-Edges: 122 | Out-Edges: 38 | Explore Neighborhood | Download JSON


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