Provenance

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charles.hoyt@scai.fraunhofer.de at 2018-04-03 15:18:35
Authors
Causal Biological Networks Database
Contact
CausalBiologicalNetworks.RD@pmi.com
Description
The PGE2 network depicts the pathways exerting regulatory control of PGE2 in the context of cellular proliferation. The network includes cAMP-mediated activation of PKA-, Epac/Rap1- and Tiam1/Vav2-dependent pathways of Rac1 activation.
License
Please cite: - www.causalbionet.com - https://bionet.sbvimprover.com as well as any relevant publications. The sbv IMPROVER project, the website and the Symposia are part of a collaborative project designed to enable scientists to learn about and contribute to the development of a new crowd sourcing method for verification of scientific data and results. The current challenges, website and biological network models were developed and are maintained as part of a collaboration among Selventa, OrangeBus and ADS. The project is led and funded by Philip Morris International. For more information on the focus of Philip Morris International’s research, please visit www.pmi.com.
Number Nodes
51
Number Edges
145
Number Components
6
Network Density
0.0568627
Average Degree
2.84314
Number Citations
102
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 71%
Selventa Protein Families Definitions v20150611 57%
PGE2-2.0-Hs v2.0 44%
PGE2-2.0-Mm v2.0 43%
Growth Factor-2.0-Rn v2.0 29%
BEL Framework Small Corpus Document v20150611 27%
Wound Healing-2.0-Rn v2.0 25%
Hedgehog-2.0-Rn v2.0 24%
Angiogenesis-2.0-Rn v2.0 24%
Hedgehog-2.0-Hs v2.0 22%

Sample Edges

a(SCHEM:Dinoprostone) increases a(SCHEM:"cyclic AMP")

both Isoproterenol and PGE2 elevate and sustain increases in cyclic adenosine 3',5'-monophosphate (cAMP) PubMed:9809467

a(SCHEM:Dinoprostone) increases a(SCHEM:"cyclic AMP")

Both PGs caused cAMP-mediated activation of PKA-, Epac/Rap1- and Tiam1/Vav2-dependent pathways of Rac1 activation PubMed:17493609

a(SCHEM:Dinoprostone) increases a(SCHEM:"cyclic AMP")

3. On human washed platelet suspensions the PGE analogues, with the exception of butaprost,inhibited the rise in adenosine 3':5'-cyclic monophosphate (cyclic AMP) induced by cicaprost (8 nM).PGE2 produced a monophasic inhibition curve (IC50 = 5.4 nM, 92% inhibition at 600 nM). PubMed:8448586

a(SCHEM:Dinoprostone) increases a(SCHEM:"cyclic AMP")

An increase of intracellular cAMP mediated by prostaglandin E2 (PGE2) has been shown to delay spontaneous apoptosis of neutrophils. PubMed:10947062

Sample Nodes

p(RGD:Il1a)

In-Edges: 8 | Out-Edges: 14 | Explore Neighborhood | Download JSON

p(RGD:Creb1)

In-Edges: 54 | Out-Edges: 15 | Explore Neighborhood | Download JSON

p(HGNC:CXCL8)

In-Edges: 334 | Out-Edges: 142 | Explore Neighborhood | Download JSON

p(HGNC:CREB1)

In-Edges: 122 | Out-Edges: 38 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.