Table of Contents

Contradictory Statements 2

These pairs of nodes have a contradiction in their causal relationships, meaning they have more than one of INCREASES, DECREASES, or CAUSES NO CHANGE. This may be due to different experimental conditions, so these statements need to be carefully considered in analyses.

Source Relations Target
p(RGD:Nfkbia) increases, decreases complex(SCOMP:"Nfkb Complex")
p(RGD:Ptk2b) increases, decreases a(CHEBI:"nitric oxide")

Unstable Pairs 1

Chaotic Pairs
Nodes that mutually increase each other, such as when both A increases B and B increases A.
Dampened Pairs
Nodes that mutually decrease each other, such as when both A decreases B and B decreases A.

While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.

Type Node A Node B
Dampened p(RGD:Nfkbia) p(RGD:Nfkbia)

Contradictory Triplets 5

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both A positiveCorrelation B, B negativeCorrelation C, but C positiveCorrelation A.
Mutually Unstable Triplets
When both A negativeCorrelation B, B negativeCorrelation C, and C negativeCorrelation A.
Jens Contradictory Triplet
When A increases B, A decreases C, and C positiveCorrelation A.
Increase Mismatch Triplet
When A increases B, A increases C, and C negativeCorrelation A.
Decrease Mismatch Triplet
When A decreases B, A decreases C, and C negativeCorrelation A.
Type Node A Node B Node C
Jens a(SCHEM:"Smoke, cigarette") path(MESHD:"Pulmonary Disease, Chronic Obstructive") p(RGD:Muc5b)
Jens p(RGD:Nfkbia) p(RGD:Nfkbia) p(RGD:Nfkbia)
Jens a(CHEBI:"reactive oxygen species") complex(p(RGD:Map3k5), p(RGD:Txn1)) p(RGD:Map3k5)
Jens a(CHEBI:ozone) a(CHEBI:"reactive oxygen species") path(MESHD:"Pulmonary Disease, Chronic Obstructive")
Jens complex(SCOMP:"Nfkb Complex") p(RGD:Nfkbia) p(RGD:Nfkbia)

Causal Pathologies 7

Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.

Source Relation Target
path(MESHD:Hyperoxia) increases a(CHEBI:"reactive oxygen species")
path(MESHD:Hyperoxia) increases p(RGD:Mapk1)
path(MESHD:Hyperoxia) increases p(RGD:Mapk3)
path(MESHD:Hyperoxia) increases p(RGD:Nfkbia)
path(MESHD:Hyperoxia) increases p(SFAM:"SRC Family")
path(MESHD:Hyperoxia) decreases r(RGD:Mir29b1)
path(SDIS:"mitochondrial DNA damage") increases a(CHEBI:"reactive oxygen species")


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