Upload at 2018-04-03 15:18:15
Causal Biological Networks Database
The Osmotic Stress network depicts the causal mechanisms that regulate osmotic stress including NFAT5, aquaporins, and CFTR pathways downstream of the hyperosmotic response.
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 63%
Osmotic Stress-2.0-Hs v2.0 42%
Osmotic Stress-2.0-Mm v2.0 41%
Oxidative Stress-2.0-Rn v2.0 37%
Epithelial Mucus Hypersecretion-2.0-Rn v2.0 36%
Growth Factor-2.0-Rn v2.0 29%
Epithelial Innate Immune Activation-2.0-Rn v2.0 27%
Hypoxic Stress-2.0-Rn v2.0 25%
Senescence-2.0-Rn v2.0 24%
Neutrophil Signaling-2.0-Rn v2.0 22%

Sample Edges

act(complex(SCOMP:"AMP Activated Protein Kinase Complex"), ma(kin)) directlyIncreases p(HGNC:CFTR, pmod(Ph, Ser, 768))

AMPK phosphorylates CFTR in vitro at two essential serines (Ser(737) and Ser(768)) in the R domain, PubMed:19095655

act(complex(SCOMP:"AMP Activated Protein Kinase Complex"), ma(kin)) directlyIncreases p(HGNC:CFTR, pmod(Ph, Ser, 768))

AMPK-dependent CFTR phosphorylation renders the channel resistant to activation by PKA and PKC without preventing phosphorylation by these kinases. We found that Ser768, a CFTR R domain residue considered to be an inhibitory PKA site, is the dominant site of AMPK phosphorylation in vitro. Ser-to-Ala mutation at this site enhanced baseline CFTR activity and rendered CFTR resistant to inhibition by AMPK PubMed:19419994

bp(GOBP:"response to osmotic stress") association bp(GOBP:"nucleotide-excision repair, DNA damage recognition")

Acute elevation of NaCl causes DNA double-strand breaks in cell culture, and the DNA breaks persist even after the cells are adapted to high NaCl. Other:14983007

a(CHEBI:aldosterone) increases act(complex(SCOMP:"NADPH Oxidase Complex"), ma(cat))

Addition of aldosterone to neonatal rat cardiac myocytes caused the activation of NADPH oxidase and intracellular ROS production in a dose-dependent manner (10-(9)-10(-7) mol/L). NADPH oxidase activation was evident as soon as 5 min after aldosterone treatment. PubMed:18360057

Sample Nodes

a(CHEBI:"reactive oxygen species")

In-Edges: 1023 | Out-Edges: 827 | Classes: 1 | Children: 4 | Explore Neighborhood | Download JSON


In-Edges: 129 | Out-Edges: 96 | Explore Neighborhood | Download JSON


In-Edges: 14 | Out-Edges: 120 | Explore Neighborhood | Download JSON


In-Edges: 44 | Out-Edges: 26 | Explore Neighborhood | Download JSON


In-Edges: 9 | Out-Edges: 1 | Explore Neighborhood | Download JSON


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