Upload at 2018-04-03 15:18:09
Causal Biological Networks Database
The Nuclear Receptors network depicts the causal mechanisms in the nuclear receptor signaling pathway that leads to cell proliferation and cell cycle progression as indicated by the core elements (cyclin-dependent kinases, E2F family members, cyclins, and CDKN1A). \nReviewed during Jamboree2014
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 68%
Cell Cycle-2.0-Rn v2.0 39%
Selventa Protein Families Definitions v20150611 26%
Nuclear Receptors-2.0-Hs v2.0 23%
Nuclear Receptors-2.0-Mm v2.0 23%
Macrophage Signaling-2.0-Rn v2.0 19%
Hox-2.0-Rn v2.0 19%
Cell Interaction-2.0-Rn v2.0 16%
Growth Factor-2.0-Rn v2.0 16%
Notch-2.0-Rn v2.0 16%

Sample Edges

p(RGD:Cdkn1a) directlyDecreases act(p(RGD:Cdk4), ma(kin))

The encoded protein (CDKN1A) binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes PubMed:12769686

p(RGD:Cdkn1a) directlyDecreases act(p(RGD:Cdk4), ma(kin))

hese results indicate that glucocorticoid inhibition of fibroblast proliferation is due to induction of p21Cip1, which binds to and inactivates cyclinD/Cdk4 complexes. PubMed:9139801

p(RGD:Cdkn1a) directlyDecreases act(p(RGD:Cdk4), ma(kin))

p21Cip1 overexpression also inhibited the kinase activity of Cdk4, though to a lesser extent than Cdk2 (data not shown). PubMed:11463845

Sample Nodes


In-Edges: 58 | Out-Edges: 21 | Explore Neighborhood | Download JSON


In-Edges: 9 | Out-Edges: 3 | Explore Neighborhood | Download JSON


In-Edges: 13 | Out-Edges: 1 | Explore Neighborhood | Download JSON


In-Edges: 24 | Out-Edges: 6 | Explore Neighborhood | Download JSON


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