The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|BEL Framework Large Corpus Document v20170611||68%|
|Cell Cycle-2.0-Rn v2.0||39%|
|Selventa Protein Families Definitions v20150611||26%|
|Nuclear Receptors-2.0-Hs v2.0||23%|
|Nuclear Receptors-2.0-Mm v2.0||23%|
|Macrophage Signaling-2.0-Rn v2.0||19%|
|Cell Interaction-2.0-Rn v2.0||16%|
|Growth Factor-2.0-Rn v2.0||16%|
The encoded protein (CDKN1A) binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes
hese results indicate that glucocorticoid inhibition of fibroblast proliferation is due to induction of p21Cip1, which binds to and inactivates cyclinD/Cdk4 complexes.
p21Cip1 overexpression also inhibited the kinase activity of Cdk4, though to a lesser extent than Cdk2 (data not shown).
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.