These pairs of nodes have a contradiction in their causal relationships, meaning they have more than one of `INCREASES`, `DECREASES`, or `CAUSES NO CHANGE`. This may be due to different experimental conditions, so these statements need to be carefully considered in analyses.

Source Relations Target
p(RGD:Ifng) increases, decreases p(HGNC:CXCL8)

### Unstable Pairs 5

Chaotic Pairs
Nodes that mutually increase each other, such as when both `A increases B` and ```B increases A```.
Dampened Pairs
Nodes that mutually decrease each other, such as when both `A decreases B` and ```B decreases A```.

While neither chaotic nor dampened pairs are biologically invalid, they require additional context to understand their regulation.

Type Node A Node B
Chaotic complex(SCOMP:"Nfkb Complex") p(HGNC:CXCL8)
Chaotic p(RGD:Map3k7) p(RGD:Tnf)
Chaotic complex(SCOMP:"Nfkb Complex") complex(SCOMP:"Nfkb Complex")
Chaotic complex(SCOMP:"Nfkb Complex") p(RGD:Tnf)
Dampened p(RGD:Nfkbia) p(RGD:Nfkbia)

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both `A positiveCorrelation B`, `B negativeCorrelation C`, but `C positiveCorrelation A`.
Mutually Unstable Triplets
When both `A negativeCorrelation B`, `B negativeCorrelation C`, and `C negativeCorrelation A`.
When `A increases B`, `A decreases C`, and ```C positiveCorrelation A```.
Increase Mismatch Triplet
When `A increases B`, `A increases C`, and ```C negativeCorrelation A```.
Decrease Mismatch Triplet
When `A decreases B`, `A decreases C`, and ```C negativeCorrelation A```.
Type Node A Node B Node C
Jens p(RGD:Tnf) p(RGD:Tnfrsf1a) p(SFAM:"MAPK p38 Family")
Jens a(CHEBI:"reactive oxygen species") complex(SCOMP:"NADPH Oxidase Complex") p(SFAM:"MAPK p38 Family")
Jens complex(SCOMP:"Nfkb Complex") complex(SCOMP:"Nfkb Complex") p(RGD:Tnf)
Jens a(CHEBI:"reactive oxygen species") complex(SCOMP:"NADPH Oxidase Complex") p(RGD:Mapk1)
Jens a(CHEBI:"reactive oxygen species") complex(SCOMP:"NADPH Oxidase Complex") p(HGNC:CXCL8)
Jens p(RGD:Nfkbia) p(RGD:Nfkbia) p(RGD:Nfkbia)
Jens p(RGD:Ccl3) p(RGD:Ccr5) p(SFAM:"MAPK p38 Family")
Jens a(CHEBI:superoxide) complex(SCOMP:"Nfkb Complex") p(HGNC:CXCL8)
Jens a(CHEBI:"reactive oxygen species") complex(SCOMP:"NADPH Oxidase Complex") p(RGD:Mapk3)
Jens complex(SCOMP:"Nfkb Complex") complex(SCOMP:"Nfkb Complex") p(HGNC:CXCL8)
Jens complex(SCOMP:"Nfkb Complex") p(RGD:Map3k7) p(RGD:Tnf)
Jens a(CHEBI:"reactive oxygen species") p(HGNC:CXCL8) p(RGD:Cxcr2)
Jens p(RGD:Map3k7) p(RGD:Tnf) p(SFAM:"MAPK p38 Family")
Jens complex(SCOMP:"Nfkb Complex") complex(SCOMP:"Nfkb Complex") complex(SCOMP:"Nfkb Complex")

### Unstable Triplets 11

Like unstable pairs, unstable triplets require additional context to understand their mechanisms of regulation.

Chaotic Triplets
A triplet of nodes that mutually increase each other, such as when ```A increases B```, `B increases C`, and `C increases A`.
Dampened Triplets
A triplet of nodes that mutually decreases each other, such as when ```A decreases B```, `B decreases C`, and `C decreases A`.
Type Node A Node B Node C
Chaotic p(RGD:Tnf) p(RGD:Tnfrsf1a) p(SFAM:"MAPK p38 Family")
Chaotic a(CHEBI:"reactive oxygen species") complex(SCOMP:"NADPH Oxidase Complex") p(SFAM:"MAPK p38 Family")
Chaotic complex(SCOMP:"Nfkb Complex") complex(SCOMP:"Nfkb Complex") p(RGD:Tnf)
Chaotic a(CHEBI:"reactive oxygen species") complex(SCOMP:"NADPH Oxidase Complex") p(RGD:Mapk1)
Chaotic a(CHEBI:"reactive oxygen species") complex(SCOMP:"NADPH Oxidase Complex") p(HGNC:CXCL8)
Chaotic p(RGD:Ccl3) p(RGD:Ccr5) p(SFAM:"MAPK p38 Family")
Chaotic a(CHEBI:"reactive oxygen species") complex(SCOMP:"NADPH Oxidase Complex") p(RGD:Mapk3)
Chaotic complex(SCOMP:"Nfkb Complex") complex(SCOMP:"Nfkb Complex") p(HGNC:CXCL8)
Chaotic complex(SCOMP:"Nfkb Complex") p(RGD:Map3k7) p(RGD:Tnf)
Chaotic a(CHEBI:"reactive oxygen species") p(HGNC:CXCL8) p(RGD:Cxcr2)
Chaotic p(RGD:Map3k7) p(RGD:Tnf) p(SFAM:"MAPK p38 Family")