Upload at 2018-04-03 15:17:57
Causal Biological Networks Database
The Neutrophil Signaling network depicts the causal mechanisms that lead to various cellular functions in neutrophils, such as polarization, extravasation, respiratory burst, response to stimuli, and chemotaxis, in response to upstream signals such as CSF3, TNF, IL8, CXCL12, F2, and FPR1. \nReviewed during Jamboree2014\nReviewed during Jamboree2015
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 59%
Epithelial Innate Immune Activation-2.0-Rn v2.0 45%
Dendritic Cell Signaling-2.0-Rn v2.0 44%
Tissue Damage-2.0-Rn v2.0 44%
Immune Regulation of Tissue Repair-2.0-Rn v2.0 42%
Macrophage Signaling-2.0-Rn v2.0 40%
Neutrophil Signaling-2.0-Hs v2.0 37%
Epithelial Mucus Hypersecretion-2.0-Rn v2.0 36%
Neutrophil Signaling-2.0-Mm v2.0 35%
NK Signaling-2.0-Rn v2.0 35%

Sample Edges

act(complex(SCOMP:"IkappaB Kinase Complex"), ma(kin)) directlyIncreases p(HGNC:NFKBIA, pmod(Ph, Ser, 36))

In the classical NF-{kappa}B signaling pathway, IKK{beta} is both necessary and sufficient for phosphorylation of I{kappa}B{alpha} on Ser 32 and Ser 36, and I{kappa}B{beta} on Ser 19 and Ser 23. PubMed:15371334

act(complex(SCOMP:"IkappaB Kinase Complex"), ma(kin)) directlyIncreases p(HGNC:NFKBIA, pmod(Ph, Ser, 36))

The IKK immunoprecipitates from thrombin-treated cells showed increased phosphorylation of GST-IkBalpha compared with the immunoprecipitates from control cells (Fig. 6), indicating the activation of IKK by thrombin. PubMed:15843586

Sample Nodes

p(SFAM:"MAPK p38 Family")

In-Edges: 300 | Out-Edges: 234 | Explore Neighborhood | Download JSON


In-Edges: 277 | Out-Edges: 1541 | Explore Neighborhood | Download JSON


In-Edges: 11 | Out-Edges: 19 | Explore Neighborhood | Download JSON


In-Edges: 81 | Out-Edges: 91 | Explore Neighborhood | Download JSON

a(CHEBI:"reactive oxygen species")

In-Edges: 1023 | Out-Edges: 827 | Classes: 1 | Children: 4 | Explore Neighborhood | Download JSON


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