Table of Contents

Contradictory Triplets 5

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both A positiveCorrelation B, B negativeCorrelation C, but C positiveCorrelation A.
Mutually Unstable Triplets
When both A negativeCorrelation B, B negativeCorrelation C, and C negativeCorrelation A.
Jens Contradictory Triplet
When A increases B, A decreases C, and C positiveCorrelation A.
Increase Mismatch Triplet
When A increases B, A increases C, and C negativeCorrelation A.
Decrease Mismatch Triplet
When A decreases B, A decreases C, and C negativeCorrelation A.
Type Node A Node B Node C
Jens a(CHEBI:glutathione) a(CHEBI:"reactive oxygen species") p(RGD:Smpd3)
Jens a(CHEBI:ceramide) a(CHEBI:"reactive oxygen species") p(RGD:Smpd2)
Jens a(CHEBI:ATP) a(CHEBI:"arachidonic acid") bp(GOBP:"necrotic cell death")
Jens a(CHEBI:ceramide) a(CHEBI:"reactive oxygen species") p(RGD:Smpd3)
Jens a(CHEBI:acetylcysteine) a(CHEBI:glutathione) a(CHEBI:"reactive oxygen species")

Unstable Triplets 2

Like unstable pairs, unstable triplets require additional context to understand their mechanisms of regulation.

Chaotic Triplets
A triplet of nodes that mutually increase each other, such as when A increases B, B increases C, and C increases A.
Dampened Triplets
A triplet of nodes that mutually decreases each other, such as when A decreases B, B decreases C, and C decreases A.
Type Node A Node B Node C
Chaotic a(CHEBI:ceramide) a(CHEBI:"reactive oxygen species") p(RGD:Smpd2)
Chaotic a(CHEBI:ceramide) a(CHEBI:"reactive oxygen species") p(RGD:Smpd3)

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