The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|BEL Framework Large Corpus Document v20170611||43%|
|Oxidative Stress-2.0-Rn v2.0||40%|
|Selventa Protein Families Definitions v20150611||31%|
|NFE2L2 Signaling-2.0-Hs v2.0||24%|
|NFE2L2 Signaling-2.0-Mm v2.0||24%|
|BEL Framework Small Corpus Document v20150611||14%|
|Dendritic Cell Signaling-2.0-Rn v2.0||13%|
|Epithelial Mucus Hypersecretion-2.0-Rn v2.0||13%|
In related experiments, the majority of the Nrf2S40-phosphorylated protein was found localized in the nucleus (Fig. 5D, lower panel).
## from full text ## coexpression of the GFP fusion protein with Keap1 and the Nrf2(S40E) mutant, in which Ser40 was replaced with Glu to mimic constitutive phosphorylation, showed nuclear accumulation in the absence of stimulus (Fig. 4, B and C),
However, after oxidative stress induced by a variety of agents, Keap1 redistributed and accumulated in the nucleus (Fig. 1A and D). This redistribution was not unique to NIH 3T3 fibroblasts. In the human hepatoblastoma cell line HepG2 (Fig. 1B), as well as in Cos7 fibroblasts (Fig. 1C), endogenous Keap1 also accumulated in the nucleus after DEM treatment.
Dietary curcumin led to increase in NF-E2-related factor-2 (Nrf2) protein levels and enhanced its nuclear translocation in liver and lungs of mice as compared with controls.
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