Upload at 2018-04-03 15:17:34
Causal Biological Networks Database
The NFE2L2 Signaling network depicts the causal mechanisms that are involved in transcriptional activation of NFE2L2 (central mediator of the cellular oxidative stress response), its interaction with MAF proteins, and its downstream target genes such as ATF4, GCLC, NQO1, and PRDX1.\u003c/p\u003e\n\u003ch2\u003eJamboree Review Focus\u003c/h2\u003e\n\u003cp\u003eInteraction of NFE2L2 with MAF proteins. Reviewed during Jamboree2014
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Number Nodes
Number Edges
Number Components
Network Density
Average Degree
Number Citations
Number BEL Errors

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 43%
Oxidative Stress-2.0-Rn v2.0 40%
Selventa Protein Families Definitions v20150611 31%
NFE2L2 Signaling-2.0-Hs v2.0 24%
NFE2L2 Signaling-2.0-Mm v2.0 24%
BEL Framework Small Corpus Document v20150611 14%
Fibrosis-2.0-Rn v2.0 14%
Apoptosis-2.0-Rn v2.0 13%
Dendritic Cell Signaling-2.0-Rn v2.0 13%
Epithelial Mucus Hypersecretion-2.0-Rn v2.0 13%

Sample Edges

p(HGNC:NFE2L2, pmod(Ph, Ser, 40)) directlyIncreases tloc(p(HGNC:NFE2L2), fromLoc(GOCC:cytoplasm), toLoc(GOCC:nucleus))

In related experiments, the majority of the Nrf2S40-phosphorylated protein was found localized in the nucleus (Fig. 5D, lower panel). PubMed:19920073

p(HGNC:NFE2L2, pmod(Ph, Ser, 40)) directlyIncreases tloc(p(HGNC:NFE2L2), fromLoc(GOCC:cytoplasm), toLoc(GOCC:nucleus))

## from full text ## coexpression of the GFP fusion protein with Keap1 and the Nrf2(S40E) mutant, in which Ser40 was replaced with Glu to mimic constitutive phosphorylation, showed nuclear accumulation in the absence of stimulus (Fig. 4, B and C), PubMed:12700136

bp(GOBP:"response to oxidative stress") increases tloc(p(MGI:Keap1), fromLoc(GOCC:cytoplasm), toLoc(GOCC:nucleus))

However, after oxidative stress induced by a variety of agents, Keap1 redistributed and accumulated in the nucleus (Fig. 1A and D). This redistribution was not unique to NIH 3T3 fibroblasts. In the human hepatoblastoma cell line HepG2 (Fig. 1B), as well as in Cos7 fibroblasts (Fig. 1C), endogenous Keap1 also accumulated in the nucleus after DEM treatment. PubMed:15899855

a(CHEBI:curcumin) increases tloc(p(HGNC:NFE2L2), fromLoc(GOCC:cytoplasm), toLoc(GOCC:nucleus))

Dietary curcumin led to increase in NF-E2-related factor-2 (Nrf2) protein levels and enhanced its nuclear translocation in liver and lungs of mice as compared with controls. PubMed:18321868

Sample Nodes

p(SFAM:"MAPK p38 Family")

In-Edges: 300 | Out-Edges: 234 | Explore Neighborhood | Download JSON


In-Edges: 8 | Out-Edges: 91 | Classes: 4 | Explore Neighborhood | Download JSON


In-Edges: 173 | Out-Edges: 60 | Explore Neighborhood | Download JSON


In-Edges: 233 | Out-Edges: 67 | Explore Neighborhood | Download JSON


In-Edges: 67 | Out-Edges: 59 | Explore Neighborhood | Download JSON


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