Name
Focal TBI
Annospace Keyword
TBItype
Annospace Name
TBI_D1_CVBio_SCAI_8-3-2018
Annospace Version
20180331
Annospace URL
https://owncloud.scai.fraunhofer.de/index.php/s/erGqWnzeLeTTXZ5/download?path=%2F&files=TBItype.belanno

Sample Edges 5

path(HP:"Impaired visuospatial constructive cognition") association path(MESHD:"Brain Injuries, Traumatic")

a(MESHC:"Granulocyte-Macrophage Colony-Stimulating Factor") decreases path(MESHD:Bacteremia)

They found that while G-CSF treatment had no impact on the frequency of pneumonia or urinary tract infections, it was associated with a significant reduction in the frequency of primary bacteremias (167). PubMed:26594196

Annotations
NCBI Taxonomy Ids
9606
Cell Ontology (CL)
natural killer cell
MeSH
Brain Injuries, Traumatic
MeSH
Blood
TBI_D1_CVBio_SCAI_8-3-2018
placebo controlled, double blinded multicentre phase II study
TBI_D1_CVBio_SCAI_8-3-2018
21 days post-injury
TBI_D1_CVBio_SCAI_8-3-2018
lipopolysaccharide treatment
TBI_D1_CVBio_SCAI_8-3-2018
sub-concussive head hits
TBI_D1_CVBio_SCAI_8-3-2018
Disease state
TBI_D1_CVBio_SCAI_8-3-2018
Focal TBI
TBI_D1_CVBio_SCAI_8-3-2018
Diffuse TBI
TBI_D1_CVBio_SCAI_8-3-2018
Head trauma

a(MESHC:"Granulocyte-Macrophage Colony-Stimulating Factor") causesNoChange path(MESHD:Pneumonia)

They found that while G-CSF treatment had no impact on the frequency of pneumonia or urinary tract infections, it was associated with a significant reduction in the frequency of primary bacteremias (167). PubMed:26594196

Annotations
NCBI Taxonomy Ids
9606
Cell Ontology (CL)
natural killer cell
MeSH
Brain Injuries, Traumatic
MeSH
Blood
TBI_D1_CVBio_SCAI_8-3-2018
placebo controlled, double blinded multicentre phase II study
TBI_D1_CVBio_SCAI_8-3-2018
21 days post-injury
TBI_D1_CVBio_SCAI_8-3-2018
lipopolysaccharide treatment
TBI_D1_CVBio_SCAI_8-3-2018
sub-concussive head hits
TBI_D1_CVBio_SCAI_8-3-2018
Disease state
TBI_D1_CVBio_SCAI_8-3-2018
Focal TBI
TBI_D1_CVBio_SCAI_8-3-2018
Diffuse TBI
TBI_D1_CVBio_SCAI_8-3-2018
Head trauma

a(MESHC:"Granulocyte-Macrophage Colony-Stimulating Factor") decreases path(MESHD:Pneumonia)

The group found that compared to patients who did not receive G-CSF therapy, prevalence rates of pneumonia and meningitis were significantly lower in G-CSF treated patients (147). Moreover, compared to baseline values, G-CSF treatment resulted in a significant increase in circulating neutrophil numbers and antimicrobial function with respect to phagocytic and bactericidal activities, suggesting that an enhancement in immune function had protected the patients from contracting nosocomial infection (147). PubMed:26594196

Annotations
NCBI Taxonomy Ids
9606
Cell Ontology (CL)
natural killer cell
MeSH
Brain Injuries, Traumatic
MeSH
Blood
TBI_D1_CVBio_SCAI_8-3-2018
placebo controlled, double blinded multicentre phase II study
TBI_D1_CVBio_SCAI_8-3-2018
21 days post-injury
TBI_D1_CVBio_SCAI_8-3-2018
lipopolysaccharide treatment
TBI_D1_CVBio_SCAI_8-3-2018
sub-concussive head hits
TBI_D1_CVBio_SCAI_8-3-2018
Disease state
TBI_D1_CVBio_SCAI_8-3-2018
Focal TBI
TBI_D1_CVBio_SCAI_8-3-2018
Diffuse TBI
TBI_D1_CVBio_SCAI_8-3-2018
Head trauma

a(MESHC:"Granulocyte-Macrophage Colony-Stimulating Factor") causesNoChange path(MESHD:"Urinary Tract Infections")

They found that while G-CSF treatment had no impact on the frequency of pneumonia or urinary tract infections, it was associated with a significant reduction in the frequency of primary bacteremias (167). PubMed:26594196

Annotations
NCBI Taxonomy Ids
9606
Cell Ontology (CL)
natural killer cell
MeSH
Brain Injuries, Traumatic
MeSH
Blood
TBI_D1_CVBio_SCAI_8-3-2018
placebo controlled, double blinded multicentre phase II study
TBI_D1_CVBio_SCAI_8-3-2018
21 days post-injury
TBI_D1_CVBio_SCAI_8-3-2018
lipopolysaccharide treatment
TBI_D1_CVBio_SCAI_8-3-2018
sub-concussive head hits
TBI_D1_CVBio_SCAI_8-3-2018
Disease state
TBI_D1_CVBio_SCAI_8-3-2018
Focal TBI
TBI_D1_CVBio_SCAI_8-3-2018
Diffuse TBI
TBI_D1_CVBio_SCAI_8-3-2018
Head trauma

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