Name
TBI with loss of consciousness
Annospace Keyword
TBItype
Annospace Name
TBI_D1_CVBio_SCAI_8-3-2018
Annospace Version
20180331
Annospace URL
https://owncloud.scai.fraunhofer.de/index.php/s/erGqWnzeLeTTXZ5/download?path=%2F&files=TBItype.belanno

Sample Edges 5

path(MESHD:"Brain Injuries, Traumatic") association path(MESHD:"Post-Concussion Syndrome")

Results indicate that previous TBI with LOC was associated with greater somatic complaints (BSI Somatic), depression (BSI Depression) and anxiety (BSI Anxiety), lower life satisfaction (SWLS), more postconcussive (RPQ-13) and -traumatic stress (PCL-C) symptoms at 6-month follow-up, and worse processing speed (WAIS-IV PSI) and verbal learning (CVLT-II Trails 1–5). PubMed:23924069

path(MESHD:"Brain Injuries, Traumatic") increases path(MESHD:"Alzheimer Disease")

Veterans 281 with severe TBI with loss of consciousness (LOC) or prolonged post- 282 traumatic amnesia (PTA) were 4 timesmore likely to have AD, whereas 283 veterans with moderate TBI were twice as likely to have AD in late-life 284 compared to controls PubMed:25758552

path(MESHD:"Brain Injuries, Traumatic") association path(MESHD:Dementia)

A single moderate to severe TBI with loss of consciousness (LOC) is 220 associated with a 4 fold increased risk of dementia in later life. The dementia is most often catego- 223 rized as probable or possible Alzheimer's disease (AD) using validated 224 clinical criteria, but fewstudies included neuropathological verification, 225 and clinical overlaps between AD, CTE and other post-traumatic 226 neurodegenerations are known to occur PubMed:25758552

path(MESHD:"Brain Injuries, Traumatic") increases p(HGNC:GFAP)

ANOVAshowed a significant difference across groups ( p < 0.001); Tukey post hoc test demonstrated that healthy controls and patients with acute TBI reporting no previous TBI constituted a statistically different subgroup in AutoAb[GFAP] levels than patients with acute TBI reporting previous TBI either with or without LOC (Fig. 1). PubMed:26560343

Annotations
NCBI Taxonomy Ids
9606
MeSH
Plasma
TBI_D1_CVBio_SCAI_8-3-2018
TBI with loss of consciousness
TBI_D1_CVBio_SCAI_8-3-2018
TBI without loss of consciousness
TBI_D1_CVBio_SCAI_8-3-2018
Repetitive mild TBI
TBI_D1_CVBio_SCAI_8-3-2018
Acute TBI

path(MESHD:Unconsciousness) increases path(MESHD:Sclerosis)

There was no association between TBI with LOC <1 hour and any neuropathological finding except Lewy bodies in frontal or temporal cortex in ROS and MAP. People with TBI with LOC>1 hour had increased risk for cerebral microinfarcts in ROS and MAP and hippocampal sclerosis and Lewy bodies in ACT. PubMed:27400367

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.