Name
Mild-to-moderate TBI
Annospace Keyword
TBItype
Annospace Name
TBI_D1_CVBio_SCAI_8-3-2018
Annospace Version
20180331
Annospace URL
https://owncloud.scai.fraunhofer.de/index.php/s/erGqWnzeLeTTXZ5/download?path=%2F&files=TBItype.belanno

Sample Edges 5

path(MESHD:"Brain Injuries, Traumatic") decreases tloc(p(HGNC:HCRTR1), fromLoc(GOCC:intracellular), toLoc(GOCC:"extracellular space"))

Decreased secretion of hypocretin 1 (a neuropeptide involved in sleep-wake regulation) in the acute phase after TBI has been described by Baumann and colleagues. PubMed:26067127

Annotations
NCBI Taxonomy Ids
9606
MeSH
Brain Injuries, Traumatic
TBI_D1_CVBio_SCAI_8-3-2018
Mild-to-moderate TBI

path(MESHD:"Brain Injuries, Traumatic") increases tloc(p(HGNC:AQP4), fromLoc(GOCC:"astrocyte end-foot"), toLoc(GOCC:"cell body"))

Ren et al. (2013) developed a closed head injury (CHI) model (the “Hit and Run” Model) of TBI in mice where they induced TBI of varying severity while maintaining the integrity of the cranial cavity, and then measured the effects on GS functioning (Ren et al., 2013). They found that mild to moderate TBI altered AQP4 channel distribution in WT mice, resulting in reduced polarization of these channels at astrocytic end feet. This reduction in polarization was due largely to a differential distribution in AQP4 away from the end feet toward the soma of perivascular astrocytes; this alteration appears to begin 3 days post-injury in both mild and moderate models of injury. In mTBI, perivascular AQP4 channels re-localized to astrocytic end feet, thus normalizing polarization, within 14–28 days, whereas in moderate TBI normalization in AQP4 distribution had not occurred by 28 days (Ren et al., 2013). These results suggest protracted physiological recovery and delayed normalization of AQP4 distribution is a function of injury severity. Additionally, alterations in AQP4 expression following TBI were associated with the degree of astrogliosis (accumulation of astrocytes around the injury site) in moderate TBI. Shifts in AQP4 polarization at the end feet of astrocytes appeared to be more closely related to the progression of reactive astrogliosis than altered protein expression (e.g., GFAP) following injury (Ren et al., 2013). PubMed:28859995

Annotations
NCBI Taxonomy Ids
10090
Uberon
glymphatic system
Cell Ontology (CL)
noradrenergic neuron
MeSH
Brain Injuries, Traumatic
MeSH
Astrocytes
TBI_D1_CVBio_SCAI_8-3-2018
3 days post-injury
TBI_D1_CVBio_SCAI_8-3-2018
closed head injury
TBI_D1_CVBio_SCAI_8-3-2018
Mild-to-moderate TBI

p(HGNC:HCRTR1) biomarkerFor path(MESHD:Narcolepsy)

Reduced hypocretin concentrations are a marker of narcolepsy type 1 and have been postulated to play a part in excessive daytime sleepiness after TBI. PubMed:26067127

Annotations
NCBI Taxonomy Ids
9606
MeSH
Brain Injuries, Traumatic
TBI_D1_CVBio_SCAI_8-3-2018
Mild-to-moderate TBI

p(HGNC:HCRTR1) increases bp(GOBP:"regulation of circadian sleep/wake cycle")

Decreased secretion of hypocretin 1 (a neuropeptide involved in sleep-wake regulation) in the acute phase after TBI has been described by Baumann and colleagues. PubMed:26067127

Annotations
NCBI Taxonomy Ids
9606
MeSH
Brain Injuries, Traumatic
TBI_D1_CVBio_SCAI_8-3-2018
Mild-to-moderate TBI

path(MESHD:Narcolepsy) decreases p(HGNC:HCRTR1)

Reduced hypocretin concentrations are a marker of narcolepsy type 1 and have been postulated to play a part in excessive daytime sleepiness after TBI. PubMed:26067127

Annotations
NCBI Taxonomy Ids
9606
MeSH
Brain Injuries, Traumatic
TBI_D1_CVBio_SCAI_8-3-2018
Mild-to-moderate TBI

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