Name
Inflicted TBI
Annospace Keyword
TBItype
Annospace Name
TBI_D1_CVBio_SCAI_8-3-2018
Annospace Version
20180331
Annospace URL
https://owncloud.scai.fraunhofer.de/index.php/s/erGqWnzeLeTTXZ5/download?path=%2F&files=TBItype.belanno

Sample Edges 5

path(MESHD:"Brain Injuries, Traumatic") decreases p(HGNC:ICAM1)

In a small pediatric study (n=16), Berger et al. (2009) used five multiplex bead assays to investigate 44 markers in the serum of well-appearing infants with mild iTBI. Nine markers showed significant increases (matrix metallopeptidase-9, hepatocyte growth factor, fibrinogen, IL-6) or decreases (Intracellular cell adehesion molecule-1 ICAM, vascular cellular adhesion molecule VCAM, eotaxin, tumor necrosis factor receptor 2, IL-12). VCAM and IL-6, the two markers that showed the greatest change were 87% sensitive and 90% specific for identifying mild iTBI. Since VCAM was decreased and unlikely to easily be used as a biomarker, IL-6 and MMP-9 were also analyzed and gave a sensitivity of 81% and specificity up to 94%. PubMed:25981889

path(MESHD:"Brain Injuries, Traumatic") increases p(HGNC:HGF)

In a small pediatric study (n=16), Berger et al. (2009) used five multiplex bead assays to investigate 44 markers in the serum of well-appearing infants with mild iTBI. Nine markers showed significant increases (matrix metallopeptidase-9, hepatocyte growth factor, fibrinogen, IL-6) or decreases (Intracellular cell adehesion molecule-1 ICAM, vascular cellular adhesion molecule VCAM, eotaxin, tumor necrosis factor receptor 2, IL-12). VCAM and IL-6, the two markers that showed the greatest change were 87% sensitive and 90% specific for identifying mild iTBI. Since VCAM was decreased and unlikely to easily be used as a biomarker, IL-6 and MMP-9 were also analyzed and gave a sensitivity of 81% and specificity up to 94%. PubMed:25981889

path(MESHD:"Brain Injuries, Traumatic") decreases p(HGNC:IL12B)

In a small pediatric study (n=16), Berger et al. (2009) used five multiplex bead assays to investigate 44 markers in the serum of well-appearing infants with mild iTBI. Nine markers showed significant increases (matrix metallopeptidase-9, hepatocyte growth factor, fibrinogen, IL-6) or decreases (Intracellular cell adehesion molecule-1 ICAM, vascular cellular adhesion molecule VCAM, eotaxin, tumor necrosis factor receptor 2, IL-12). VCAM and IL-6, the two markers that showed the greatest change were 87% sensitive and 90% specific for identifying mild iTBI. Since VCAM was decreased and unlikely to easily be used as a biomarker, IL-6 and MMP-9 were also analyzed and gave a sensitivity of 81% and specificity up to 94%. PubMed:25981889

path(MESHD:"Brain Injuries, Traumatic") increases p(HGNC:IL6)

In a small pediatric study (n=16), Berger et al. (2009) used five multiplex bead assays to investigate 44 markers in the serum of well-appearing infants with mild iTBI. Nine markers showed significant increases (matrix metallopeptidase-9, hepatocyte growth factor, fibrinogen, IL-6) or decreases (Intracellular cell adehesion molecule-1 ICAM, vascular cellular adhesion molecule VCAM, eotaxin, tumor necrosis factor receptor 2, IL-12). VCAM and IL-6, the two markers that showed the greatest change were 87% sensitive and 90% specific for identifying mild iTBI. Since VCAM was decreased and unlikely to easily be used as a biomarker, IL-6 and MMP-9 were also analyzed and gave a sensitivity of 81% and specificity up to 94%. PubMed:25981889

path(MESHD:"Brain Injuries, Traumatic") decreases p(HGNC:TNFRSF1B)

In a small pediatric study (n=16), Berger et al. (2009) used five multiplex bead assays to investigate 44 markers in the serum of well-appearing infants with mild iTBI. Nine markers showed significant increases (matrix metallopeptidase-9, hepatocyte growth factor, fibrinogen, IL-6) or decreases (Intracellular cell adehesion molecule-1 ICAM, vascular cellular adhesion molecule VCAM, eotaxin, tumor necrosis factor receptor 2, IL-12). VCAM and IL-6, the two markers that showed the greatest change were 87% sensitive and 90% specific for identifying mild iTBI. Since VCAM was decreased and unlikely to easily be used as a biomarker, IL-6 and MMP-9 were also analyzed and gave a sensitivity of 81% and specificity up to 94%. PubMed:25981889

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