Name
Neoplasms
Annospace Keyword
MeSHDisease
Annospace Name
MeSH
Annospace Version
20170511
Annospace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Edges 5

bp(GOBP:"response to stress") increases p(HGNC:SIRT3)

While this observation on its own does not prove the dual role of SirT3, it is nevertheless consistent with the possibility that in areas of the tumor experiencing local mitochondrial stress, SirT3 is upregulated. PubMed:25274306

act(p(HGNC:JUN), ma(tscript)) increases r(HGNC:CCND1)

Thus, Pin1 is up-regulated in human tumors and cooperates with Ras signaling in increasing c-Jun transcriptional activity towards cyclin D1. PubMed:11432833

Annotations
NCBI Taxonomy Ids
9606
MeSH
Neoplasms
NeuroMMSigDB
MAPK-ERK subgraph

act(p(HGNC:JUN), ma(tscript)) association p(HGNC:MAPK8)

Moreover, Pin1 cooperates with either activated Ras or JNK to increase transcriptional activity of c-Jun towards the cyclin D1 promoter. PubMed:11432833

act(p(HGNC:JUN), ma(tscript)) association p(SFAM:"RAS Family")

Moreover, Pin1 cooperates with either activated Ras or JNK to increase transcriptional activity of c-Jun towards the cyclin D1 promoter. PubMed:11432833

path(MESHD:"Arthritis, Rheumatoid") association p(HGNC:MMP3)

Also matrix metalloproteinase-3 (MMP-3) or stromelysin-1 contributes to several pathologies, such as cancer, asthma and rheumatoid arthritis, and has also been associated with neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and multiple sclerosis. PubMed:22862420

About

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