Name
10090
Annospace Keyword
Species
Annospace Name
NCBI Taxonomy Ids
Annospace Version
20170430
Annospace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/species-taxonomy-id/species-taxonomy-id-20170511.belanno

Sample Edges 5

path(MESHF:Anxiety) negativeCorrelation p(MGI:Grin1)

Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development. Consistent with the NMDAR hypofunction theory of schizophrenia, distinct schizophrenia-related symptoms emerged after adolescence, including novelty-induced hyperlocomotion, mating and nest-building deficits, as well as anhedonia-like and anxiety-like behaviors. PubMed:19915563

path(MESHF:Anxiety) positiveCorrelation path(MESHF:"Depressive Disorder, Major")

Mice that were rendered heterozygous for the γ2 subunit of GABAA receptors (γ2(+/-) mice) have been characterized extensively as a model for major depressive disorder. The phenotype of these mice includes behavior indicative of heightened anxiety, despair, and anhedonia, as well as defects in hippocampus-dependent pattern separation, HPA axis hyperactivity and increased responsiveness to antidepressant drugs. PubMed:25107590

path(MESHF:Anxiety) positiveCorrelation p(MGI:Gabrg2)

Mice that were rendered heterozygous for the γ2 subunit of GABAA receptors (γ2(+/-) mice) have been characterized extensively as a model for major depressive disorder. The phenotype of these mice includes behavior indicative of heightened anxiety, despair, and anhedonia, as well as defects in hippocampus-dependent pattern separation, HPA axis hyperactivity and increased responsiveness to antidepressant drugs. PubMed:25107590

path(MESHF:Anxiety) negativeCorrelation a(CHEBI:tryptophan)

To this aim, we administered, to outbred CD1 mouse dams, during their first week of lactation, a tryptophan deficient diet (T) and corticosterone via drinking water (C; 80μg/ml). Four groups of dams (animal facility rearing, AFR; T treated, T; C treated, C; T and C treated, TC) and their male offspring were used in the study.T, C and TC treatments reduced active maternal care compared to AFR. Adult TC offspring showed significantly increased anxiety- and anhedonia-related behaviours, reduced striatal and increased hypothalamic BDNF and reduced dopamine and serotonin in the prefrontal cortex and their turnover in the hippocampus. PubMed:22613034

Annotations
NCBI Taxonomy Ids
10090
Anhedonia_Model_Deliverable_1.2
approach-avoidance conflict paradigm
Anhedonia_Model_Deliverable_1.2
CD-1
Anhedonia_Model_Deliverable_1.2
adult offspring

About

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