Name
9606
Annospace Keyword
Species
Annospace Name
NCBI Taxonomy Ids
Annospace Version
20170430
Annospace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/species-taxonomy-id/species-taxonomy-id-20170511.belanno

Sample Edges 5

act(p(HGNC:DUSP1), ma(phos)) directlyDecreases act(p(SFAM:"MAPK p38 Family"), ma(kin))

The dual specificity protein phosphatase MAPK phosphatase-1(MKP-1) has been shown to dephosphorylate and inactivate ERK2, SAPK, and p38 MAPK in transient transfection studies. PubMed:9202001

Annotations
Experimental Factor Ontology (EFO)
U-937 cell
NCBI Taxonomy Ids
9606

act(p(HGNC:DUSP1), ma(phos)) decreases act(p(HGNC:JUN), ma(tscript))

This differential substrate specificity of MKP-1 can be functionally extended to nuclear transcriptional events in that PMAinduced c-Jun transcriptional activity was more sensitive to inhibition by MKP-1 than either Elk-1 or c-Myc. PubMed:9202001

Annotations
Experimental Factor Ontology (EFO)
U-937 cell
NCBI Taxonomy Ids
9606

act(p(HGNC:DUSP1), ma(phos)) directlyDecreases act(p(HGNC:MAPK1), ma(kin))

The dual specificity protein phosphatase MAPK phosphatase-1(MKP-1) has been shown to dephosphorylate and inactivate ERK2, SAPK, and p38 MAPK in transient transfection studies. PubMed:9202001

Annotations
Experimental Factor Ontology (EFO)
U-937 cell
NCBI Taxonomy Ids
9606

act(p(HGNC:DUSP1), ma(phos)) directlyDecreases p(SFAM:"MAPK p38 Family", pmod(Ph))

The dual specificity protein phosphatase MAPK phosphatase-1(MKP-1) has been shown to dephosphorylate and inactivate ERK2, SAPK, and p38 MAPK in transient transfection studies. PubMed:9202001

Annotations
Experimental Factor Ontology (EFO)
U-937 cell
NCBI Taxonomy Ids
9606

act(p(HGNC:DUSP1), ma(phos)) directlyDecreases p(HGNC:MAPK1, pmod(Ph))

The dual specificity protein phosphatase MAPK phosphatase-1(MKP-1) has been shown to dephosphorylate and inactivate ERK2, SAPK, and p38 MAPK in transient transfection studies. PubMed:9202001

Annotations
Experimental Factor Ontology (EFO)
U-937 cell
NCBI Taxonomy Ids
9606

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.